2918768-05-3
Chemical Structure
Cardiotoxin Analog (CTX) IV (6-12) TFA
- CAS No.: 2918768-05-3
- Formula:C50H71F3N10O9
- Molecular Weight:1013.16
IUPAC Name: (S)-1-(L-leucyl-L-isoleucyl-L-prolyl)-N-((S)-1-(((S)-1-(((S)-1,6-diamino-1-oxohexan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate
InChIKey: GHUKFCBMUNPTER-PUGIKGIGSA-N
SMILES: NCCCC[C@@H](C(N)=O)NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CC3=CC=CC=C3)NC([C@H]4N(C([C@H]5N(C([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)N)=O)=O)CCC5)=O)CCC4)=O)=O)=O.OC(C(F)(F)F)=O
Biological Activity: Cardiotoxin Analog (CTX) IV (6-12) TFA is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) TFA was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) TFA is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) TFA can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cardiotoxin Analog (CTX) IV (6-12) TFA | 99.58% | Cardiotoxin Analog (CTX) IV (6-12) TFA is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) TFA was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) TFA is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) TFA can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Kaneda N, et al. The amino acid sequence of cardiotoxin-analogue IV from the venom of Naja naja atra. FEBS Lett. 1976 Nov;70(1):217-22. [Content Brief]
- [2]. Dufourcq J, et al. Structure-function relationships for cardiotoxins interacting with phospholipids. Toxicon. 1982;20(1):165-74. [Content Brief]
