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moulting hormone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) Caspase (2) Drug Intermediate (1) Endogenous Metabolite (3) Insecticide (1) Reference Standards (1)
By Research Areas:	Cardiovascular Disease (2) Endocrinology (1) Infection (3)

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Targets Recommended: Thyroid Hormone Receptor PTHR GHR Nuclear Hormone Receptor 4A/NR4A TSH Receptor MCHR1 (GPR24) GHSR Hormone-Sensitive Lipase (HSL) GnRH Receptor

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-N6979

Crustecdysone 10+ Cited Publications 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-128030

Makisterone A	Others	Endocrinology
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

HY-N17267

2-Deoxy-20-hydroxyecdysone	Others	Infection
2-Deoxy-20-hydroxyecdysone is an ecdysteroid. 2-Deoxy-20-hydroxyecdyson can be isolated from zoanthid Zoanthus sp.. 2-Deoxy-20-hydroxyecdysone exhibits lower moulting hormone activity than 20-hydroxyecdysone in Musca bioassays .

HY-N6979R

Crustecdysone (Standard) 20-Hydroxyecdysone (Standard)	Reference Standards Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-N13069

2-Deoxy-20-hydroxyecdysone-22-phosphate	Drug Intermediate	Infection
2-Deoxy-20-hydroxyecdysone-22-phosphate is an inactive storage form of insect ecdysteroids. 2-Deoxy-20-hydroxyecdysone-22-phosphate exists in newly laid eggs of the desert locust Schistocerca gregaria. 2-Deoxy-20-hydroxyecdysone-22-phosphate can be enzymatically hydrolyzed by embryonic tissues to release the ecdysteroid 2-deoxy-20-hydroxyecdysone (HY-N17267) .

HY-118989

Ajugalactone	Insecticide Endogenous Metabolite	Infection
Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both ecdysone (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation .

Crustecdysone 10+ Cited Publications 20-Hydroxyecdysone	Cardiovascular Disease other families Animals Classification of Application Fields Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Disease Research Fields Steroids Source Classification	Caspase Autophagy Endogenous Metabolite
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

Makisterone A	Classification of Application Fields Chenopodium quinoa Willd. Plants Disease Research Fields Endocrinology Steroids Source Classification Chenopodiaceae	Others
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

2-Deoxy-20-hydroxyecdysone	Structural Classification Marine natural products Other marine organisms Steroids Source Classification	Others
2-Deoxy-20-hydroxyecdysone is an ecdysteroid. 2-Deoxy-20-hydroxyecdyson can be isolated from zoanthid Zoanthus sp.. 2-Deoxy-20-hydroxyecdysone exhibits lower moulting hormone activity than 20-hydroxyecdysone in Musca bioassays .

Crustecdysone (Standard) 20-Hydroxyecdysone (Standard)	Structural Classification other families Animals Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Steroids Source Classification	Reference Standards Caspase Autophagy Endogenous Metabolite
Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

2-Deoxy-20-hydroxyecdysone-22-phosphate	Structural Classification Natural Products Animals Source Classification	Drug Intermediate
2-Deoxy-20-hydroxyecdysone-22-phosphate is an inactive storage form of insect ecdysteroids. 2-Deoxy-20-hydroxyecdysone-22-phosphate exists in newly laid eggs of the desert locust Schistocerca gregaria. 2-Deoxy-20-hydroxyecdysone-22-phosphate can be enzymatically hydrolyzed by embryonic tissues to release the ecdysteroid 2-deoxy-20-hydroxyecdysone (HY-N17267) .

Ajugalactone	Structural Classification Labiatae Plants Steroids Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Insecticide Endogenous Metabolite
Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both ecdysone (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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moulting hormone

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