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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

mouse splenic cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arp2/3 Complex (1) C-type Lectin-like Receptors (CTLRs) (1) CD19 (1) CD20 (1) CD3 (1) CDK (1) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (1) NF-κB (1) Opioid Receptor (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (7) Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-120350

BI-1347 5+ Cited Publications	CDK	Cancer
BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC₅₀=1.1 nM). BI-1347 shows anti-tumoral activity .

HY-P99124

Anti-Mouse CD3 Antibody (17A2) 1 Publications Verification	CD3	Inflammation/Immunology
Anti-Mouse CD3 Antibody (17A2) is an anti-mouse CD3 IgG2b antibody inhibitor derived from the host Rat. Anti-Mouse CD3 Antibody (17A2) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic T cells. Anti-Mouse CD3 Antibody (17A2) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models .

HY-P99976

Anti-Mouse CD19 Antibody (1D3)	CD19	Inflammation/Immunology
Anti-Mouse CD19 Antibody (1D3) is an IgG2a antibody inhibitor targeting mouse CD19. Anti-Mouse CD19 Antibody (1D3) reduces CD19 expression levels on the surface of B cells. Anti-Mouse CD19 Antibody (1D3) inhibits the replication of peritoneal B-1a cells .

HY-101307

BNTX maleate 7-Benzylidenenaltrexone maleate	Opioid Receptor	Neurological Disease
BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the K_is of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity .

HY-145492

Δ7(Z)-C14-HSL N-(3-Oxo-7Z-tetradecenoyl)-L-homoserine lactone	Drug Derivative	Inflammation/Immunology
Δ7(Z)-C14-HSL (Compound 12) is an immunosuppressive agent that can inhibit the proliferation of mouse splenic cells with an IC₅₀ of 17 μM. Δ7(Z)-C14-HSL can be used for further studying its potential as a molecular mechanism in TNF-R-driven immune diseases, especially autoimmune diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes .

HY-130757

Remisporine B	Endogenous Metabolite	Inflammation/Immunology
Remisporine B is a polyketide, that can be isolated from Penicillium sp. ZJ-SY2. Remisporine B exhibits immunosuppressive efficacy, that inhibits concanavalin A (HY-P2149)-induced T-cell proliferation and LPS (HY-D1056)- induced B-cell proliferations of mouse splenic lymphocytes with IC₅₀ of 30.1 µg/mL and 32.4 µg/mL .

HY-P992071

Anti-Mouse NKG2D Antibody (MI6)	C-type Lectin-like Receptors (CTLRs)	Inflammation/Immunology
Anti-Mouse NKG2D Antibody (MI6) is an antibody targeting mouse NKG2D. Anti-Mouse NKG2D Antibody (MI6) can be used in arthritis-related research. For the isotype control of Anti-Mouse NKG2D Antibody (MI6), please refer to Rat IgG1 kappa, Isotype Control (HY-P99979) .

HY-186205

(Rac)-EGC-M5	Drug Metabolite	Cancer
(Rac)-EGC-M5 is an orally active metabolite of green tea Catechin (EGC) (HY-N0898). (Rac)-EGC-M5 enhances the activity of CD4 ⁺ T cells. (Rac)-EGC-M5 boosts the cytotoxic activity of NK cells in vivo. (Rac)-EGC-M5 can be used in cancer-related research .

HY-P992060

Anti-Mouse CD20 Antibody (18B12)	CD20 NF-κB	Inflammation/Immunology Cancer
Anti-Mouse CD20 Antibody (18B12) is a B cell depleting agent that targets mouse CD20. Anti-Mouse CD20 Antibody (18B12) not only inhibits the growth of mesothelioma, lung cancer and thymoma, but also significantly enhances the efficacy of adenoviral tumor antigen vaccines and induces tumor regression by increasing the number of tumor-specific CD8 ⁺ T cells. Anti-Mouse CD20 Antibody (18B12) reduces B cell infiltration into the central nervous system of mice with experimental autoimmune encephalomyelitis, and delays motor dysfunction and neuronal death after spinal cord injury by alleviating inflammatory responses and tissue damage. Anti-Mouse CD20 Antibody (18B12) is widely applicable to research in fields related to mesothelioma, lung cancer, thymoma, experimental autoimmune encephalomyelitis and spinal cord injury .

HY-182487

Deoxaphomin	Arp2/3 Complex	Inflammation/Immunology
Deoxaphomin is a cytochalasin. Deoxaphomin inhibits Actin filament elongation and reduces the viscosity of polymerized actin filaments. Deoxaphomin induces rounding of fibroblasts, contraction of actin cables, formation of actin-containing hairy structures, and formation of actin-containing cytoplasmic rodlets in fibroblasts. Deoxaphomin inhibits membrane ruffling in fibroblasts and capping in lymphocytes .

Cat. No.	Nombre del producto	Target	Research Area	Image

HY-P99124

Anti-Mouse CD3 Antibody (17A2) 1 Publications Verification	CD3	Inflammation/Immunology
Anti-Mouse CD3 Antibody (17A2) is an anti-mouse CD3 IgG2b antibody inhibitor derived from the host Rat. Anti-Mouse CD3 Antibody (17A2) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic T cells. Anti-Mouse CD3 Antibody (17A2) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models .

HY-P99976

Anti-Mouse CD19 Antibody (1D3)	CD19	Inflammation/Immunology
Anti-Mouse CD19 Antibody (1D3) is an IgG2a antibody inhibitor targeting mouse CD19. Anti-Mouse CD19 Antibody (1D3) reduces CD19 expression levels on the surface of B cells. Anti-Mouse CD19 Antibody (1D3) inhibits the replication of peritoneal B-1a cells .

HY-P992071

Anti-Mouse NKG2D Antibody (MI6)	C-type Lectin-like Receptors (CTLRs)	Inflammation/Immunology
Anti-Mouse NKG2D Antibody (MI6) is an antibody targeting mouse NKG2D. Anti-Mouse NKG2D Antibody (MI6) can be used in arthritis-related research. For the isotype control of Anti-Mouse NKG2D Antibody (MI6), please refer to Rat IgG1 kappa, Isotype Control (HY-P99979) .

HY-P992060

Anti-Mouse CD20 Antibody (18B12)	CD20 NF-κB	Inflammation/Immunology Cancer
Anti-Mouse CD20 Antibody (18B12) is a B cell depleting agent that targets mouse CD20. Anti-Mouse CD20 Antibody (18B12) not only inhibits the growth of mesothelioma, lung cancer and thymoma, but also significantly enhances the efficacy of adenoviral tumor antigen vaccines and induces tumor regression by increasing the number of tumor-specific CD8 ⁺ T cells. Anti-Mouse CD20 Antibody (18B12) reduces B cell infiltration into the central nervous system of mice with experimental autoimmune encephalomyelitis, and delays motor dysfunction and neuronal death after spinal cord injury by alleviating inflammatory responses and tissue damage. Anti-Mouse CD20 Antibody (18B12) is widely applicable to research in fields related to mesothelioma, lung cancer, thymoma, experimental autoimmune encephalomyelitis and spinal cord injury .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-130757

Remisporine B	Microorganisms Xanthones Phenols Source Classification	Endogenous Metabolite
Remisporine B is a polyketide, that can be isolated from Penicillium sp. ZJ-SY2. Remisporine B exhibits immunosuppressive efficacy, that inhibits concanavalin A (HY-P2149)-induced T-cell proliferation and LPS (HY-D1056)- induced B-cell proliferations of mouse splenic lymphocytes with IC₅₀ of 30.1 µg/mL and 32.4 µg/mL .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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mouse splenic cells

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Natural
Products