864461-31-4
Chemical Structure
BNTX maleate
Synonym(s): 7-Benzylidenenaltrexone maleate
- CAS No.: 864461-31-4
- Formula:C31H31NO8
- Molecular Weight:545.58
IUPAC Name: (4R,4aS,7aR,12bS,E)-6-benzylidene-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one maleate
InChIKey: GKHUUKGUNNYVGB-LQDKARLYSA-N
SMILES: O[C@@]1(C/C2=C\C3=CC=CC=C3)[C@]4([C@@](C2=O)([H])OC5=C6O)C5=C(C=C6)C[C@@]1([H])N(CC7CC7)CC4.OC(/C=C\C(O)=O)=O
Biological Activity: BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the Kis of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BNTX maleate | 98.2% | BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the Kis of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity. | ||||||||||||||||||||
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- [1]. Portoghese PS, et al. A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone. Eur J Pharmacol. 1992;218(1):195-196. [Content Brief]
- [2]. House RV, et al. Suppression of immune function by non-peptidic delta opioid receptor antagonists. Neurosci Lett. 1995 Sep 29;198(2):119-22. [Content Brief]
Keywords
