(Rac)-EGC-M5
(Rac)-EGC-M5 is an orally active metabolite of green tea Catechin (EGC) (HY-N0898). (Rac)-EGC-M5 enhances the activity of CD4+ T cells. (Rac)-EGC-M5 boosts the cytotoxic activity of NK cells in vivo. (Rac)-EGC-M5 can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 1299471-83-2
- Formula: C11H12O4
- Molecular Weight:208.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(Rac)-EGC-M5 (10 μM; 72 h) significantly increases relative ATP levels in isolated mouse splenic CD4+ T cells after 72 h incubation, enhancing CD4+ T cell activation[1].
(Rac)-EGC-M5 (5-50 μM; 72 h) significantly upregulates PHA-induced IFN-γ production in isolated mouse splenocytes, while having no significant effect on PHA-induced IL-2 levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse spleen cells
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Concentration:10, 25 and 50 μM
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Incubation Time:72 h
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Result:Significantly upregulated the secretion of IFN-γ induced by PHA.
Was no significant change in the level of IL-2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice (male, 8-10 weeks old)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Increased splenic NK cell cytotoxicity against YAC-1 target cells to ~330% of control at an effector:target ratio of 20:1 and ~350% of control at an effector:target ratio of 40:1.
Increased the percentage of granzyme B+ NK cells to ~0.42%.
Showed no significant effect on populations of perforin+ NK cells, IFN-γ+ NK cells, IFN-γ+ CD8+ cells, helper T cells, cytotoxic T cells, B cells, dendritic cells, macrophages, total NK cells, Th1 cells, Th2 cells, Th17 cells, or Treg cells.
Chemical Information
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CAS No. 1299471-83-2
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Molecular Weight 208.21
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Formula C11H12O4
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SMILES
O=C1OC(CC1)CC2=CC(O)=CC(O)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-EGC-M5 Related Classifications
HY-186205 Related Classifications
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