(Rac)-EGC-M5
(Rac)-EGC-M5 is an orally active metabolite of green tea Catechin (EGC) (HY-N0898). (Rac)-EGC-M5 enhances the activity of CD4+ T cells. (Rac)-EGC-M5 boosts the cytotoxic activity of NK cells in vivo. (Rac)-EGC-M5 can be used in cancer-related research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1299471-83-2
- Formule: C11H12O4
- Masse moléculaire:208.21
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
(Rac)-EGC-M5 (10 μM; 72 h) significantly increases relative ATP levels in isolated mouse splenic CD4+ T cells after 72 h incubation, enhancing CD4+ T cell activation[1].
(Rac)-EGC-M5 (5-50 μM; 72 h) significantly upregulates PHA-induced IFN-γ production in isolated mouse splenocytes, while having no significant effect on PHA-induced IL-2 levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Mouse spleen cells
-
Concentration:10, 25 and 50 μM
-
Incubation Time:72 h
-
Result:Significantly upregulated the secretion of IFN-γ induced by PHA.
Was no significant change in the level of IL-2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c mice (male, 8-10 weeks old)[1]
-
Dosage:10 mg/kg
-
Administration:p.o.; daily; 14 days
-
Result:Increased splenic NK cell cytotoxicity against YAC-1 target cells to ~330% of control at an effector:target ratio of 20:1 and ~350% of control at an effector:target ratio of 40:1.
Increased the percentage of granzyme B+ NK cells to ~0.42%.
Showed no significant effect on populations of perforin+ NK cells, IFN-γ+ NK cells, IFN-γ+ CD8+ cells, helper T cells, cytotoxic T cells, B cells, dendritic cells, macrophages, total NK cells, Th1 cells, Th2 cells, Th17 cells, or Treg cells.
Chemical Information
-
CAS No. 1299471-83-2
-
Masse moléculaire 208.21
-
Formule C11H12O4
-
SMILES
O=C1OC(CC1)CC2=CC(O)=CC(O)=C2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-EGC-M5 Related Classifications
HY-186205 Related Classifications
Powered by Bioz