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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
p27kip1
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "p27kip1" in MCE Product Catalog:
3
SJ572403 (SJ403) is a p27 Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) .
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Camprenstat (GGTI-2418) is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. Camprenstat inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. Camprenstat also increases p27(Kip1) and induces significant regression of breast tumors .
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Cat. No.: HY-N8884
CAS No.: 82344-82-9
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CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently (IC50=1.72 μM) inhibits the ubiquitination of p27 Kip1, as confirmed by dose-response analysis.
Cat. No.: HY-W412264
CAS No.: 6320-51-0
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27 Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer .
Cat. No.: HY-103436
CAS No.: 13116-77-3
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NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation .
Cat. No.: HY-16230
CAS No.: 501010-05-5
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GGTI-2417 is a potent and selective inhibitor of GGTase I. GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27 Kip1 at Thr187 and accumulates p27 Kip1 in the nucleus. GGTI-2417 also induces breast cancer cell apoptosis .
Cat. No.: HY-RS19053
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Cdkn1b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdkn1b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-117513
CAS No.: 189036-01-9
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CEP1612 is a dipeptidyl proteasome inhibitor with the IC50 of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo .
Cat. No.: HY-129108
CAS No.: 205252-57-9
Synonyms: (9Z)-UAB-30
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9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs). 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43). 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer .
Cat. No.: HY-P70037
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CDKN1B; p27kip1; Cyclin Dependent Kinase Inhibitor 1B; Truncated Cyclin-Dependent Kinase Inhibitor 1B; KIP1; MEN1B; Cyclin-Dependent Kinase Inhibitor 1B; CDKN4; p27kip1; MEN4; Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1); P27; Cyclin-Dependent Kinase
Cat. No.: HY-N13904
CAS No.: 174423-37-1
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Cat. No.: HY-RS02412
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CDKN1B Human Pre-designed siRNA Set A contains three designed siRNAs for CDKN1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
