189036-01-9
189036-01-9
Chemical Structure
CEP1612
- CAS No.: 189036-01-9
- Formula:C35H53N7O7
- Molecular Weight:683.84
IUPAC Name: 2-cyclopentyl-10-(1,3-dioxoisoindolin-2-yl)-N-((S)-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-5-(3-nitroguanidino)-1-oxopentan-2-yl)decanamide
InChIKey: OOEXUWDNTCTJMI-ZJHKYUCMSA-N
SMILES: O=C1C2=CC=CC=C2C(N1CCCCCCCCC(C3CCCC3)C(N[C@@H](CCCNC(NN(=O)=O)=N)C(N[C@H](C=O)CC(C)C)=O)=O)=O
Biological Activity: CEP1612 is a dipeptidyl proteasome inhibitor with the IC50 of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo[1][2].
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CEP1612 | CEP1612 is a dipeptidyl proteasome inhibitor with the IC50 of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo. | |||||||||||||||||||||
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References
- [1]. An B, et al. Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ. 1998;5(12):1062-1075. [Content Brief]
- [2]. Sun J, et al. CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice. Cancer Res. 2001;61(4):1280-1284. [Content Brief]
Keywords
