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resistant strain

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (37) Cardiovascular Disease (2) Endocrinology (1) Infection (317) Inflammation/Immunology (17) Metabolic Disease (3) Neurological Disease (3)
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337

Inhibitors & Agonists

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Peptides

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GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0402

Artemether 3 Publications Verification Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Parasite	Infection Inflammation/Immunology Cancer
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-A0086

Netilmicin sulfate SCH-20569 sulfate	Bacterial Antibiotic	Infection
Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .

HY-14267

Lersivirine UK-453061	HIV Reverse Transcriptase	Infection
Lersivirine (UK-453061) is potent and selective non-nucleoside reverse transcription inhibitor (NNRTI; IC₅₀=119 nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity against wild-type HIV virus and clinically relevant NNRTI-resistant strains .

HY-116387

WR99210 4 Publications Verification BRL 6231 free base	Dihydrofolate reductase (DHFR) Parasite	Infection
WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC₅₀<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine< (HY-18062)-resistant P. falciparum strains) as well as T. gondii .

HY-14800

Radezolid 10+ Cited Publications RX-1741	Bacterial Antibiotic	Infection
Radezolid (RX-1741) is a oxazolidinone antibiotic. Radezolid is active against *Staphylococcus, Chlamydia, and Legionella* species, and remains active against Linezolid-resistant strains .

HY-B0343A

Sarafloxacin hydrochloride 2 Publications Verification A-56620 hydrochloride	Bacterial	Infection Inflammation/Immunology
Sarafloxacin hydrochloride (A-56620 hydrochloride) is a fluoroquinolone Antibacterial agent. Sarafloxacin inhibits the growth of Staphylococcus aureus, Enterobacteriaceae, and both aminoglycoside-sensitive and aminoglycoside-resistant strains of Pseudomonas aeruginosa .

HY-15975

GNF179	Parasite	Infection
GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency (IC₅₀ of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally active .

HY-P10486

AIP-II	Bacterial	Infection
AIP-II is a cyclic peptide signaling molecule for quorum sensing, which is produced by Staphylococcus aureus. AIP-II potently inhibits AgrC-III in Methicillin (HY-121544)-resistant type III Staphylococcus aureus strain AH1747, with an IC50 of 0.532 nM. AIP-II binds to the AgrC-II receptor and regulates virulence gene expression in Staphylococcus aureus .

HY-131981

TP0586532 2 Publications Verification	Bacterial	Infection Cardiovascular Disease
TP0586532 is a non-hydroxamate LpxC inhibitor (IC₅₀=0.101 μM). TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains . TP0586532 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N3386

Licoricone	Bacterial	Infection
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-131708A

FNDR-20123	HDAC Parasite	Infection
FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC₅₀s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC₅₀=41 nM) and sexual blood stage (IC₅₀=190 nM for male gametocytes). FNDR-20123 inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC₅₀=25/29/2/11/282 nM, respectively.) and inhibits Class III HDAC isoforms at nanomolar concentrations .

HY-100358

AQ-13 dihydrochloride	Parasite	Infection
AQ-13 dihydrochloride is an aminoquinoline antimalarial agent that is effective against drug-resistant strains of Plasmodium falciparum.

HY-N0402S

Artemether-d3 Dihydroqinghaosu methyl ether-d₃; Dihydroartemisinin methyl ether-d₃; SM224-d₃	Isotope-Labeled Compounds Parasite	Infection Cancer
Artemether-d₃ is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

HY-P5714

Abaecin	Bacterial	Infection
Abaecin is an antibacterial response peptide. Abaecin shows specific activity against an Apidaecin-resistant Xanthomonas strain .

HY-135578

Artelinic acid	Parasite	Infection
Artelinic acid, a derivative of Artemisinin, is an antimalarial agent for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes .

HY-N15451

Deoxytopsentin	Pyruvate Kinase	Infection
Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro .

HY-127054

Netilmicin Sch 20569	Antibiotic Bacterial	Infection
Netilmicin (Sch 20569) is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .

HY-14891

Fosdevirine GSK2248761; FDV	HIV Reverse Transcriptase	Infection
Fosdevirine (GSK2248761) is is a potent, selective, non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) replication with low nanomolar activity in vitro. Fosdevirine shows good activity against a broad range of HIV-1 strains, including efavirenz (HY-10572)-resistant clinical isolates .

HY-146394

HBV-IN-22	HBV DNA/RNA Synthesis	Infection
HBV-IN-22 (Compound LC5f) is an inhibitor of HBV DNA replication with IC₅₀ values of 0.71 μM and 0.84 μM against wild-type and agent resistant HBV strains, respectively .

HY-N7642

Oxysanguinarine Hydroxysanguinarine; 8-Oxosanguinarine	Parasite	Infection
Oxysanguinarine (Hydroxysanguinarine;8-Oxosanguinarine) is a protoberberine alkaloid from Meconopsis simplicifolia with antimalarial activity .

HY-N10430

Patentiflorin A	HIV	Infection
Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains .

HY-B0343

Sarafloxacin A-56620	Bacterial	Infection Inflammation/Immunology
Sarafloxacin (A-56620) is a fluoroquinolone Antibacterial agent. Sarafloxacin inhibits the growth of Staphylococcus aureus, Enterobacteriaceae, and both aminoglycoside-sensitive and aminoglycoside-resistant strains of Pseudomonas aeruginosa .

HY-P5545

Lynronne-1	Bacterial	Infection
Lynronne-1 is an antimicrobial peptide. Lynronne-1 is active against Gram-positive bacterials, including MDR strains (MIC: 8-32 μg/mL for methicillin-resistant MRSA strains). Lynronne-1 reduces the bacterial load in MRSA infected wound murine model. Lynronne-1 is also effective against P. aeruginosa infection .

HY-103250

PF-945863	Antibiotic	Infection
PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains .

HY-162464

MPD2	PROTACs SARS-CoV	Infection
MPD2 is a Cereblon-binding ligand-based PROTAC that degrades MPro, the main protease of SARS-CoV-2. MPD2 effectively reduced MPro protein levels in 293T cells in a time-dependent manner (DC₅₀=296 nM). MPD2 exhibited potent antiviral activity against multiple SARS-CoV-2 strains and had enhanced potency against Nirmatrelvir (HY-138687) resistant strains. MPD2 provides a new direction for antiviral drug development against SARS-CoV-2 and other emerging coronavirus pathogens (Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker (HY-W275882)；Red: SARS-CoV-2 MPro Inhibitor MP18 (HY-158763)) .

HY-139982

OX11	Bacterial	Infection
OX11 is a selective inhibitor of S. pneumoniae, P. aeruginosa, and E. coli bacterial strains .

HY-13588A

Cefsulodin SCE-129	Bacterial Antibiotic	Others
Cefsulodin (SCE-129) showed potent activity against Pseudomonas aeruginosa and strains susceptible to penicillin and gentamicin, with effectiveness comparable to that of gentamicin and debendazole. However, its effectiveness was diminished against penicillin-resistant strains of P. aeruginosa, particularly strains that were also resistant to gentamicin. For P. aeruginosa maltofila, SCE-129 showed similar minimum inhibitory concentrations to penicillin, gentamicin, and debendazole. Pseudomonas cepacia strains generally showed moderate resistance to SCE-129 and penicillin, and high resistance to gentamicin and debendazole .

HY-116271

Sperabillin C	Antibiotic Bacterial	Infection
Sperabillin C is an antibacterial antibiotic with activity against both Gram-negative and Gram-positive bacteria, including resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus .

HY-P5547

Lynronne-3	Bacterial	Infection
Lynronne-3 is an antimicrobial peptide. Lynronne-1 is active against Gram-positive bacterials, including MDR strains (MIC: 32-128 μg/mL for methicillin-resistant MRSA strains). Lynronne-3 is also effective against P. aeruginosa infection

HY-153696

MRL-436	DNA/RNA Synthesis Bacterial	Infection
MRL-436 is a RNA polymerase inhibitor with antibacterial activity. MRL-436 exerts its antibacterial activity dependent on residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. MRL-436 inhibits Rifampicin (HY-B0272)-resistant RNA polymerase derivatives and exhibits antibacterial activity against Rifampicin-resistant strains .

HY-135847

Desmethyl ferroquine SSR97213	Parasite Drug Metabolite	Infection
Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains .

HY-170219

RMM23	Parasite Epigenetic Reader Domain	Infection
RMM23 is an inhibitor targeting PfBDP1 with a K_d value of 1.24 μM. RMM23 against the wild-type strains 3D7 and NF54, and the multidrug-resistant K1 strain in vitro blood stage, with EC₅₀ values of 18 μM, 14 μM, 20 μM, respectively .

HY-157892

Antimalarial agent 38	Parasite	Infection
Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC₅₀s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC₅₀ >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model .

HY-111746

CWHM-1008 1 Publications Verification	Parasite	Infection
CWHM-1008 is a potent and orally active antimalarial agent, with EC₅₀ values of 46 and 21 nM against agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively .

HY-P991653

HGS004	CCR HIV	Infection
HGS004 is a humanized IgG4 monoclonal antibody inhibitor targeting CCR5. HGS004 has potent antivival activity against a diverse panel of CCR5-tropic HIV-1 and durg (such as Maraviroc (HY-13004))-resistant strains. HGS004 can be used for HIV-1 infections research .

HY-N2894

Piperolactam A	Parasite	Infection
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani .

HY-144113

HIV-1 inhibitor-14	HIV	Infection
HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC₅₀ of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC₅₀s of 5.79 ~ 28.3 nM .

HY-N14706

Kibdelin A	Bacterial	Infection
Kibdelin A is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N14902

Mimosamycin	Antibiotic Bacterial	Infection
Mimosamycin is an antibiotic. Mimosamycin has activity against mycobacteria and streptomyces resistant strains .

HY-N14707

Kibdelin B	Bacterial	Infection
Kibdelin B is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N14710

Kibdelin D	Bacterial	Infection
Kibdelin D is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-119206

Sulbenicillin	Antibiotic	Others
Sulbenicillin is an antibiotic that, in a study of its activity against Pseudomonas aeruginosa infection in mice, showed differences in activity against certain strains compared to other antibiotics, and activity against gentamicin-resistant strains was affected by the strain's own resistance.

HY-N15059

Cissetin	Bacterial	Infection
Cissetin shows activity against Gram-positive bacteria, including drug-resistant strains .

HY-N14709

Kibdelin C2	Bacterial	Infection
Kibdelin C2 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N14708

Kibdelin C1	Bacterial	Infection
Kibdelin C1 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-118926

Bioresmethrin	Parasite	Others
Bioresmethrin is an insecticide that protects grain. Bioresmethrin against malathion-resistant and susceptible strains R. dominica .

HY-139631

HIV-1 inhibitor-9	HIV	Infection
HIV-1 inhibitor-9 is found to be potent inhibitor against the wild-type (WT) HIV-1 strain or multiple NNRTI-resistant strains at low nanomolar levels.

HY-169571

Antimicrobial agent-38	Bacterial	Infection
Antimicrobial agent-38 (compound 10) is a potent inhibitor of methicillin-resistant S. aureus strain ATCC 700699 and nonresistant strain ATCC 29213, with MICs of 32 and 64 mg/L .

HY-131708

FNDR-20123 free base	HDAC Parasite	Infection
FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC₅₀s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC₅₀=41 nM) and sexual blood stage (IC₅₀=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC₅₀=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations .

HY-153620

Antifungal agent 55	Fungal	Infection
Antifungal agent 55 (compound A07) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 55 is more effective than Miconazole (HY-B0454). Antifungal agent 55 inhibits Candida albicans strains with MIC values of 0.25-1 μg/mL .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0315

Allicin 15+ Cited Publications Diallyl thiosulfinate	Infection Natural Products Liliaceae Classification of Application Fields Plants Disease Research Fields A．Sativam L. var．Viviparum Regel Source Classification	Bacterial Antibiotic
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains .

HY-13067

Celastrol Maximum Cited Publications 61 Publications Verification Tripterine; Tripterin	Triterpenes Structural Classification Classification of Application Fields Anti-aging Terpenoids Celastraceae Tripterygium wilfordii Hook. f. Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	Proteasome Autophagy Mitophagy Apoptosis Endogenous Metabolite Antibiotic Bacterial Nuclear Hormone Receptor 4A/NR4A
Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-N0402

Artemether 3 Publications Verification Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Classification of Application Fields Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Source Classification Cancer	Parasite
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-B0255

Adefovir dipivoxil 2 Publications Verification GS 0840	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	HBV Orthopoxvirus HSV DNA/RNA Synthesis ATM/ATR CDK
Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the KCTD12-CDK1 interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type *strains*. Adefovir dipivoxil has antitumor activity against lung and colon cancer .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic PDI
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum aminoglycoside Antibiotic with bactericidal activity against Gram-positive cocci, Gram-negative cocci, bacilli, and drug-resistant strains. Ribostamycin sulfate also acts as an inhibitor of protein disulfide isomerase (PDI), with a binding constant K_D of 319 μM for bovine PDI. Ribostamycin sulfate targets bacterial 16S ribosomal RNA and the 30S ribosomal subunit, causing translational misreading and thereby inhibiting bacterial protein synthesis. Ribostamycin sulfate disrupts the integrity of bacterial cell membranes, induces membrane pore formation, and leads to bacterial death. Ribostamycin sulfate can be used in studies related to bacterial infections .

HY-N0248

Saikosaponin B2 2 Publications Verification	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	HCV P-glycoprotein
Saikosaponin B2 is an antiviral and anticancer agent that regulates multiple transporters (such as various solute carriers and ATP-binding cassette transporters including MRP1, MRP2, and OCT2). Saikosaponin B2 is isolated from the plant glycoside component of the roots of Bupleurum scorzonerifolium. Saikosaponin B2 enhances the liver targeting of anticancer drugs via vinegar-baked Radix Bupleuri. Saikosaponin B2 inhibits HCV entry, replication, and translation, is effective against Daclatasvir (HY-10466)-resistant strains, and exerts a synergistic effect when used in combination with Daclatasvir. Saikosaponin B2 is commonly used in studies related to hepatocellular carcinoma and HCV infection .

HY-N1136

(+)-Totarol	Infection Animals Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Source Classification	Bacterial
(+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections .

HY-N1050

Zederone	Terpenoids Sesquiterpenes Plants Curcuma elata Roxb. Source Classification Zingiberaceae	mTOR Ribosomal S6 Kinase (RSK) Bacterial
Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC₅₀s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD₅₀ value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis .

HY-103249

Reutericyclin Reutericycline	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Reutericyclin (Reutericycline) is an orally active antibacterial and anti-obesity agent that selectively inhibits Gram-positive bacteria. By selectively dissipating transmembrane potential, Reutericyclin exerts non-lytic bactericidal or bacteriostatic activity against pathogens such as Clostridium difficile and Staphylococcus aureus, and rapidly kills vegetative cells and spores of Clostridium difficile. Reutericyclin possesses favorable properties including resistance to enzymatic hydrolysis, iron-chelating function, and poor absorption by colonic epithelium. Reutericyclin not only eradicates staphylococcal biofilms and inhibits drug-resistant strains, but also counteracts Risperidone (HY-11018)-induced weight gain by inducing changes in gut microbiota composition and restoring energy utilization efficiency. Reutericyclin can be used in research related to Clostridium difficile infection, Risperidone-induced weight gain, and staphylococcal superficial skin infections .

HY-N3386

Licoricone	Infection Flavonoids Monophenols Classification of Application Fields Leguminosae Phenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones Source Classification	Bacterial
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-N5109

Cheilanthifoline	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Parasite
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-P5714

Abaecin	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Abaecin is an antibacterial response peptide. Abaecin shows specific activity against an Apidaecin-resistant Xanthomonas strain .

HY-N15451

Deoxytopsentin	Structural Classification Alkaloids Marine natural products Sponge Indole Alkaloids Source Classification	Pyruvate Kinase
Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro .

HY-N7634

Tectol	Infection other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Farnesyl Transferase Parasite
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-N7642

Oxysanguinarine Hydroxysanguinarine; 8-Oxosanguinarine	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Parasite
Oxysanguinarine (Hydroxysanguinarine;8-Oxosanguinarine) is a protoberberine alkaloid from Meconopsis simplicifolia with antimalarial activity .

HY-N10430

Patentiflorin A	Infection Classification of Application Fields Acanthaceae Justicia gendarussa N. L. Burman Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	HIV
Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains .

HY-N1074

Warangalone Scandenolone	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Source Classification Erythrina variegata Linn.	Parasite PKA
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

HY-W060074

1-Acetyl-β-carboline	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Pyridine Alkaloids Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite Bacterial Tyrosinase PERK
1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin .

HY-W134163

(E)-2-Octenal trans-2-Octenal	Structural Classification Natural Products Vitis vinifera cv. Zalema Plants Vitaceae Source Classification	Fungal Reactive Oxygen Species (ROS) Mitochondrial Metabolism Phosphatase Pyruvate Kinase
(E)-2-Octenal is an Antifungal agent. (E)-2-Octenal disrupts cell membrane integrity and causes ROS accumulation. (E)-2-Octenal decreases the activities of phosphofructokinase and pyruvate kinase. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism. (E)-2-Octenal suppresses the growth of a Prochloraz (HY-B0845)-resistant Penicillium italicum strain. (E)-2-octenal exerts a broad-spectrum and potent inhibitory effect on various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, etc. (E)-2-Octenal can be used for the research of citrus blue mold and mango stem-end rot .

HY-116271

Sperabillin C	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Sperabillin C is an antibacterial antibiotic with activity against both Gram-negative and Gram-positive bacteria, including resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus .

HY-N7010

(-)-Corynoxidine	Infection Alkaloids Classification of Application Fields Corydalis speciosa Maxim. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Cholinesterase (ChE) Bacterial
(-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC₅₀ value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa . (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees .

HY-126640

Phomoxanthone A	Quinones Microorganisms Anthraquinones Source Classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N2932

β-Yohimbine Amsonin; Amsonine; NSC 93133	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Alkaloids Aspidosperma ulei Markgr. Plants Indole Alkaloids Source Classification	Parasite
β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC₅₀: > 1 μg/mL) .

HY-135422

Nidulin Methylustin	Natural Products Microorganisms Source Classification	Bacterial Fungal
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant* Staphylococcus aureus* and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .

HY-158721

Penicinoline Marinamide	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Parasite
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-N16123

Chloranthalactone C	Terpenoids Sesquiterpenes Chloranthaceae Plants Chloranthus fortunei (A. Gray) Solms-Laub Source Classification	Parasite
Chloranthalactone C (Compound 43), a lindenane-type sesquiterpenoid, is an antimalarial agent. Chloranthalactone C can be isolated from plant Chloranthus japonicas Sieb. Chloranthalactone C inhibits Chloroquine (HY-17589A)-resistant Plasmodium falciparum strain Dd2 growth. Chloranthalactone C can be used for parasitic infections research .

HY-117845

Citreamicin alpha LL-E19085α	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Citreamicin alpha (LL-E 19085-alpha) is an antibiotic whose in vitro antimicrobial activity against 429 clinical isolates of Gram-positive cocci has been tested by the agar dilution method. These microorganisms included 313 strains of Staphylococci and 116 strains of Streptococci. The in vitro activity of Citreamicin alpha was compared with that of ampicillin, amoxicillin, ceftriaxone, erythromycin, and vancomycin. For Staphylococci, the MIC values of Citreamicin alpha ranged from 0.12-4.0 μg/ml, and for Streptococcus pyogenes of the genus Streptococcus, it was 0.03-0.12 μg/ml. However, enterococci were relatively resistant, requiring 2.0 μg/ml of the agent to inhibit 64% of the 62 tested strains. The in vitro activity of this antibiotic was much better than that of ampicillin, amoxicillin, ceftriaxone, and erythromycin, but comparable or slightly inferior to that of vancomycin.

HY-121348

Ficellomycin U-47929	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial DNA/RNA Synthesis
Ficellomycin is a nitrogen-containing bicyclic antibiotic with strong activity against Gram-positive bacteria, including multidrug-resistant strains of Staphylococcus aureus. Ficellomycin works by inducing the formation of defective 34S DNA fragments, which interfere with the semi-conservative DNA replication process. These fragments lack the ability to integrate into larger DNA segments and eventually form a complete bacterial chromosome. Ficellomycin can be used in research for various bacterial diseases .

HY-Y0367R

Maleic acid (Standard)	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Bacterial
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes. IC₅₀* & Target: GAD . In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .

HY-N16422

Mer-NF5003E	Microorganisms Terpenoids Sesquiterpenes Source Classification	HIV HIV Protease
Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC₅₀=50 μM). Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C). Mer-NF5003E is promising for research of HIV infections .

HY-W437569

Melicopine	Alkaloids Cornaceae Cornus officinalis Sieb. et Zucc. Acridone Alkaloids Plants Source Classification	Parasite Insecticide
Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC₅₀ values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC₅₀ values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC₅₀ greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields .

HY-B0255R

Adefovir dipivoxil (Standard) GS 0840 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards HBV Reverse Transcriptase Orthopoxvirus Endogenous Metabolite
Adefovir dipivoxil (Standard) is the analytical standard of Adefovir dipivoxil. This product is intended for research and analytical applications. Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the KCTD12-CDK1 interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type *strains*. Adefovir dipivoxil has antitumor activity against lung and colon cancer .

HY-N2894

Piperolactam A	Alkaloids Piper betle L. Piperaceae Plants Source Classification	Parasite
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani .

HY-N14706

Kibdelin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin A is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N14902

Mimosamycin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Mimosamycin is an antibiotic. Mimosamycin has activity against mycobacteria and streptomyces resistant strains .

HY-N14707

Kibdelin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin B is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N14710

Kibdelin D	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin D is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N15059

Cissetin	Natural Products Microorganisms Source Classification	Bacterial
Cissetin shows activity against Gram-positive bacteria, including drug-resistant strains .

HY-N14709

Kibdelin C2	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin C2 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N14708

Kibdelin C1	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin C1 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N8388

Collinin	Zanthoxylum schinifolium Sieb. et Zucc. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Bacterial
Collinin is a anti-tubercular agent, it can be isolated from leaves of Z. schinifolium. Collinin has an excellent anti-tuberculosis effect against multidrug-resistant (MDR), extensively drug-resistant (XDR) strains .

HY-N15526

Austroside A	Annona squamosa L. Plants Annonaceae Saccharides Monosaccharides Source Classification	Bacterial
Austroside A is found in Evodia austrosinensis. Austroside A shows antibacterial activity against the Staphylococcus aureus antibiotic resistant strain .

HY-N8489

1-Methoxyphaseollidin	Infection Structural Classification Classification of Application Fields Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Endogenous Metabolite Bacterial
1-Methoxyphaseollidin, a flavonoid compound, is a lysoPAF acetyltransferase inhibitor, with an IC₅₀ of 48 μM. 1-Methoxyphaseollidin exhibits anti-H.pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-N14622

Fudecalone	Natural Products Microorganisms Source Classification	Parasite
Fudecalone is found in the strain of Penicillum sp. FO-2030. Fudecalone completely inhibits Eimeria Tenella, a coccidius resistant to Monesin (HY-N4302) .

HY-N0402R

Artemether (Standard) Dihydroqinghaosu methyl ether (Standard); Dihydroartemisinin methyl ether (Standard); SM224 (Standard)	Structural Classification Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Source Classification	Reference Standards Parasite
Artemether (Standard) is the analytical standard of Artemether. This product is intended for research and analytical applications. Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Flavonoids Xanthones Calophyllum caledonicum Vieill. ex Planch. & Triana Phenols Plants Calophyllaceae Other Flavonoids Source Classification	Parasite
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-N8338

Pancixanthone A	Flavonoids Guttiferae Garcinia vieillardii Pierre Plants Other Flavonoids Source Classification	Parasite
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-121000

Albocycline Ingramycin	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Antibiotic Bacterial
Albocycline (Ingramycin) is a macrolide antibiotic, which exhibits antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin (HY-B0671)-intermediate (VISA), and Vancomycin (HY-B0671)-resistant S. aureus (VRSA) strains with MICs ranging from 0.5 to 1.0 μg/mL. Albocycline exhibits no toxicity to human cells at concentration of ≤64 μg/mL .

HY-165272

Antibiotic SF-2132	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Antibiotic
Antibiotic SF-2132 is a peptide antibiotic identified in Nocardiopsis sp., which exhibits inhibitory activity against β-lactam antibiotic-resistant strains, such as Pseudomonas and Escherichia .

Cat. No.	Product Name	Chemical Structure

HY-N0402S

Artemether-d3
Artemether-d₃ is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

HY-B0593S

Ceftazidime-d5
Ceftazidime-d₅ (GR20263-d₅) is the deuterium labeled Ceftazidime (HY-B0593). Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-W768856

Artemether-13C,d3
Artemether- ¹³C,d₃ (Dihydroqinghaosu methyl ether- ¹³C,d₃) is the deuterium and ¹³C-labeled Artemether (HY-N0402). Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-113958S

Difethialone-d4

Difethialone-d₄ (Baraki-d₄; LM 2219-d₄) is the deuterium labeled Difethialone (HY-113958). Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13067G

Celastrol Tripterine; Tripterin	Endogenous Metabolite Proteasome Antibiotic Apoptosis Bacterial Autophagy Mitophagy	Infection Inflammation/Immunology Cancer
Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

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