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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
sickle
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "sickle" in MCE Product Catalog:
54
54 Publications Verification
Cat. No.: HY-123606
CAS No.: 1652629-23-6
Target:
Domaines de recherche:
GSK484 is a PAD4 inhibitor that effectively inhibits protein citrullination and the formation of neutrophil extracellular traps (NETs) by blocking the catalytic activity of PAD4. GSK484 suppresses the production of histone H3, MHC-I expression, CD8 + T cell activation, proliferation and inflammatory cytokine release. GSK484 reduces inflammation and bone destruction in collagen-induced rheumatoid arthritis, alleviates pain and mast cell activation in sickle cell disease, and improves myocardial ischemia-reperfusion injury and experimental colitis. In addition, GSK484 restores intestinal microbial homeostasis by reversing ferroptosis-induced dysbiosis. GSK484 can be used to study the disease mechanisms of rheumatoid arthritis, sickle cell disease, thrombosis, myocardial injury, colitis and other conditions .
9
9 Cited Publications
Cat. No.: HY-D0844
CAS No.: 27025-41-8
Synonyms: L-Glutathione oxidized; GSSG; Oxiglutatione
9
Target:
Domaines de recherche:
Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment .
2
2 Cited Publications
Cat. No.: HY-D0844S
CAS No.: 1416898-83-3
Synonyms: L-Glutathione oxidized-13C4,15N2; GSSG-13C4,15N2; Oxiglutatione-13C4,15N2
1
1 Cited Publications
Synonyms: Diphosphofructose trisodium; Esafosfan trisodium; FDP trisodium
Category:
Cardiovascular Disease Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields
Target:
1
Target:
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Pociredir (FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir can induce HbF protein expression in cell and murine models. Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia .
1
Target:
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1
1 Cited Publications
Synonyms: FTX-6058 hydrochloride
Target:
Domaines de recherche:
Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir hydrochloride can induce HbF protein expression in cell and murine models. Pociredir hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia .
1
1 Cited Publications
Cat. No.: HY-N0455AS7
CAS No.: 94740-43-9
Synonyms: (S)-(+)-Arginine-13C hydrochloride
1
1 Cited Publications
Target:
Domaines de recherche:
GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity. GBT1118 increases tolerance to severe hypoxia .
1
1 Cited Publications
Cat. No.: HY-N0455AS
CAS No.: 204633-92-1
Synonyms: (S)-(+)-Arginine-15N2 hydrochloride
Cat. No.: HY-N0455AS8
CAS No.: 202468-25-5
Synonyms: (S)-(+)-Arginine-13C6,15N4 hydrochloride
Cat. No.: HY-175742
CAS No.: 3036554-12-5
Domaines de recherche:
BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research .
Cat. No.: HY-167874
CAS No.: 2488255-42-9
Domaines de recherche:
ASP-8731 is an orally active BACH1 inhibitor. ASP-8731 activates antioxidant, anti-inflammatory and globin gene pathways by relieving the inhibitory effect of BACH1 on NRF2-mediated gene transcription. ASP-8731 significantly upregulates the expression of HMOX1, FTH1 and various globins (such as HGB, HBG, HBA), increases fetal hemoglobin (HbF) levels, and effectively induces F-cell production in hydroxyurea-unresponsive cells. Meanwhile, ASP-8731 reduces inflammatory responses and white blood cell counts by downregulating VCAM1, ICAM-1 and the phosphorylation level of NF-κB(p65), and blocks heme-induced glutathione depletion and microcirculatory stasis. ASP-8731 holds potential for inhibiting sickle cell disease and related hematological disorders .
Cat. No.: HY-N0455AS2
CAS No.: 204244-77-9
Synonyms: (S)-(+)-Arginine-d7 hydrochloride
Cat. No.: HY-N0455AS6
CAS No.: 201740-91-2
Synonyms: (S)-(+)-Arginine-13C6 hydrochloride
Domaines de recherche:
Glutathione reductase, baker's yeast (EC 1.6.4.2) is a reductase. Glutathione reductase, baker's yeast eliminates intracellular ROS. Glutathione reductase, baker's yeast reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) using NADPH as an electron donor. Glutathione reductase, baker's yeast exerts antioxidant activity. Glutathione reductase is mainly used to study diseases associated with oxidative stress, such as Parkinson's disease and sickle cell anemia .
Cat. No.: HY-N0455AS1
CAS No.: 204633-95-4
Synonyms: (S)-(+)-Arginine-15N4 hydrochloride
Synonyms: GBT-601; GBT-021601
Target:
Domaines de recherche:
Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) .
Domaines de recherche:
WIZ degrader 9 is an orally active molecular glue degrader of the WIZ transcription factor. As a molecular glue, WIZ degrader 9 recruits WIZ to the cereblon E3 ubiquitin ligase complex via its ZF7 domain, driving proteasome-dependent degradation of WIZ. WIZ degrader 9 induces hemoglobin production, reduces the level of H3K9 dimethylation across the whole genome and at the β-globin locus, upregulates the transcription of γ-globin and BGLT3, and increases the level of histone H3K9 acetylation in the promoter region of HBG1/2. WIZ degrader 9 effectively induces fetal hemoglobin production in both mice and cynomolgus monkeys. WIZ degrader 9 can be used for research on sickle cell disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
