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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
tetrahydroisoquinoline derivative
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "tetrahydroisoquinoline derivative" in MCE Product Catalog:
Cat. No.: HY-139570
CAS No.: 2248127-53-7
Synonyms: PM14
Target:
Research Areas:
Ecubectedin (PM14) is a derivative. Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities .
Cat. No.: HY-113969
CAS No.: 61563-24-4
Category:
Alkaloids Neurological Disease Endogenous metabolite Disease Research Fields Isoquinoline Alkaloids
Target:
Cat. No.: HY-100296
CAS No.: 89845-16-9
Target:
Research Areas:
Gastrofensin AN 5, a 4-phenyl-tetrahydroisoquinoline derivative, is an antiulcer agent.
Cat. No.: HY-147399
CAS No.: 1206846-61-8
Target:
Research Areas:
5-HT7 agonist 2 is a potent 5-HT7 receptor agonist with an IC50 value of 28.7 nM. 5-HT7 agonist 2 can be used for research of central nervous system (CNS) disorders .
Cat. No.: HY-156079
CAS No.: 1071049-42-7
Target:
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Antidepressant agent 5 (Compound 3i) is a 7-substituted tetrahydroisoquinolines derivatives. Antidepressant agent 5 exhibits almost equal antidepressant activity compared with magnoflorine. ntidepressant agent 5 can be used for depressive disorder research .
Cat. No.: HY-100296A
CAS No.: 89845-17-0
Target:
Research Areas:
Gastrofensin AN 5, a 4-phenyl-tetrahydroisoquinoline derivative, is an antiulcer agent.
Cat. No.: HY-164726
CAS No.: 96719-63-0
Target:
Research Areas:
Estrogen receptor modulator 11 (Compound 27) is a tetrahydroisoquinoline derivative. Estrogen receptor modulator 11 has a certain affinity for estrogen receptors (ER), with IC50 values of 285 nM and 421 nM for ERα and ERβ, respectively. Estrogen receptor modulator 11 lacks antagonist activity in the MCF-7 cellular assay .
Cat. No.: HY-114214
CAS No.: 626252-75-3
Target:
Drug Derivative NF-κB MMP TNF Receptor Interleukin Related Cyclin G-associated Kinase (GAK) CDK PI3K Akt
Research Areas:
CKD-712 is an orally active multi-target tetrahydroisoquinoline derivatived and a potent inhibitor of the NF-κB pathway . CKD-712 selectively inhibits MMP-9 with no effect on MMP-2, downregulates the expression of TNF-α, IL-6, cyclin A, cyclin B, CDK-1 and other proteins, and activates the PI3K/Akt signaling pathway . CKD-712 blocks the activation and nuclear translocation of NF-κB, downregulates inflammatory factors and pro-tumor metastatic proteins, and induces G2/M phase arrest in tumor cells and thereby inhibits the invasion of cancer cells . CKD-712 can be used for the research of sepsis, myocardial ischemia-reperfusion injury and non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
