1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 

Cat. No.: HY-113969
Handling Instructions

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease.

For research use only. We do not sell to patients.

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Chemical Structure

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Chemical Structure

CAS No. : 61563-24-4

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Description

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1].

In Vivo

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) (i.p., 40 mg/kg, once daily, 3 days) has an important role in the regulation of blood pressure and changes in adrenal catecholamine levels in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive (SHR) and their age-paired normotensive Wistar-Kyoto (WKY) rats[2]
Dosage: 40 mg/kg
Administration: i.p.; once daily; 3 days
Result: Caused a decrease in blood pressure in SHR rats but no effect on blood pressure in WKY rats.
Caused a decrease in hypothalamic epinephrine (Epi) levels, norepinephrine (NE) levels and raised dopamine (DA) levels in both SHR and WKY rats.
Molecular Weight

202.08

Formula

C9H9Cl2N

CAS No.
SMILES

ClC1=C(Cl)C=CC2=C1CNCC2

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Product Name:
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Cat. No.:
HY-113969
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