7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 61563-24-4
- Formula: C9H9Cl2N
- Molecular Weight:202.08
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male spontaneously hypertensive (SHR) and their age-paired normotensive Wistar-Kyoto (WKY) rats[2]
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Dosage:40 mg/kg
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Administration:i.p.; once daily; 3 days
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Result:Caused a decrease in blood pressure in SHR rats but no effect on blood pressure in WKY rats.
Caused a decrease in hypothalamic epinephrine (Epi) levels, norepinephrine (NE) levels and raised dopamine (DA) levels in both SHR and WKY rats.
Chemical Information
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CAS No. 61563-24-4
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Appearance Solid
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Molecular Weight 202.08
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Formula C9H9Cl2N
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Color White to off-white
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SMILES
ClC1=C(Cl)C=CC2=C1CNCC2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Pramod C Nair, et al. Using Theory to Reconcile Experiment: The Structural and Thermodynamic Basis of Ligand Recognition by Phenylethanolamine N-Methyltransferase (PNMT). J Chem Theory Comput. 2011 May 10;7(5):1458-68. [Content Brief]
[2]. N Y Liang, et al. Inhibitors of phenylethanolamine-N-methyltransferase. 2. Comparison of nonaromatic analogs of phenylethanolamines, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) and 2,3-dichloro-alpha-methylbenzylamine: effects on rat brain and adrenal catecholamine content and blood pressure. J Pharmacol Exp Ther. 1982 Nov;223(2):382-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Related Classifications
HY-113969 Related Classifications
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