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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
82 Results for "
thiophene,
" in MedChemExpress (MCE) Product Catalog:
Products (82)
82 Results for "thiophene," in MCE Product Catalog:
9
9 Publications Verification
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JR14a is a potent thiophene antagonist of human complement C3a receptor. JR14a shows selectivity for the human C3a receptor over C5a receptor. JR14a can suppress C3aR-mediated inflammation .
3
3 Cited Publications
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VCH-916 is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 binds to Thumb Site II. VCH-916 can be used for the research of hepatitis c virus (hcv) infection .
2
2 Cited Publications
Synonyms: NSC55712; TPU-260 Dihydrochloride
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
TPT-260 Dihydrochloride (NSC55712), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 Dihydrochloride increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 Dihydrochloride inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 Dihydrochloride improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 Dihydrochloride exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 Dihydrochloride can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .
1
1 Cited Publications
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ML402, a thiophene-carboxamide, is a selective K2P2.1(TREK-1) and K2P10.1(TREK-2) activator. ML402 is inactive against K2P4.1(TRAAK) .
1
1 Cited Publications
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B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD) .
Cat. No.: HY-W002251
CAS No.: 5381-20-4
Cat. No.: HY-W012941
CAS No.: 98-03-3
Synonyms: Thiophene-2-carboxaldehyde
Category:
Capparis spinosa L. Ketones, Aldehydes, Acids Metabolic Disease Plants Capparidaceae Endogenous metabolite Disease Research Fields
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Synonyms: GSI-953
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Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease .
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity .
Cat. No.: HY-I0182
CAS No.: 898566-17-1
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2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl) methyl]thiophene is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-I0565
CAS No.: 1034305-17-3
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2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-W016900
CAS No.: 4282-31-9
Synonyms: Thiophene-2,5-dicarboxylate
Thiophene-2,5-dicarboxylic acid (Thiophene-2,5-dicarboxylate) is a metal-organic framework (MOF).
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Thiophene-2-amidoxime is a synthetic intermediate useful for pharmaceutical synthesis.
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Rivaroxaban impurity 50 (thiophene-2-carboxylate) is an impurity of Rivaroxaban.
Cat. No.: HY-I0207
CAS No.: 1071929-08-2
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2-(5-Iodo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-I0563
CAS No.: 1034305-11-7
Synonyms: α-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol
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Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol (α-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol) is a drug intermediate for synthesis of various active compounds.
Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis .
Cat. No.: HY-W004615
CAS No.: 88-13-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
