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transcription factor EB

" in MedChemExpress (MCE) Product Catalog:

標的別:	Autophagy (4) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (1) mTOR (1)
研究分野別:	Cancer (1) Inflammation/Immunology (1) Metabolic Disease (1)
Oligonucleotides:	Decoy ODNs (1)

阻害剤およびアゴニスト

天然物

抗体

オリゴヌクレオチド

Targets Recommended: Microphthalmia Associated Transcription Factor (MITF) OLIG2 ATF6 RUNX

製品番号	製品名	Target	研究分野	構造式

HY-N0866

20-Deoxyingenol 5 Publications Verification	Autophagy	Inflammation/Immunology
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

HY-148230

TFEB Decoy ODN sodium	Interleukin Related HIF/HIF Prolyl-Hydroxylase Autophagy	Others
TFEB Decoy ODN sodium is a synthetic oligonucleotide with a hairpin ring structure, which were designed to inhibit Transcription factor EB (TFEB). TFEB decoy ODN inhibited fibrosis and autophagy in a UUO mouse model. The TFEB decoy ODNs also showed anti-inflammatory effects.

HY-162866

CXM102	Autophagy	Metabolic Disease
CXM102 is an autophagy activator. CXM102 can induce autophagy in aged BMSCs, leading to the rejuvenation of BMSCs and preferential differentiation into osteoblasts. CXM102 promotes the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. CXM102 can stimulate bone synthesis metabolism in middle-aged male mice, reduce bone marrow adipocytes, delay bone loss, lower serum inflammation levels, decrease organ fibrosis, and extend the lifespan of the mice .

HY-124582

NEO214 1 Publications Verification	Autophagy mTOR	Cancer
NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma .

20-Deoxyingenol 5 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

Host:	Mouse (1) Rabbit (3)
Reactivity:	Human (4) Rat (1) Mouse (2)
Application:	IHC-P (4) ICC/IF (4) IP (3) IHC-F (2) WB (4) ELISA (2)
Isotype:	IgG (3) IgG1 (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P83521

	Transcription Factor EB Antibody (YA3266) TFEB; BHLHE35; transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Transcription Factor EB Antibody (YA3266) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transcription Factor EB.

HY-P85853

	Transcription Factor EB Antibody (YA5545)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse
	Transcription Factor EB Antibody (YA5545) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Transcription Factor EB.

HY-P86184

	Transcription Factor EB Antibody (YA5876)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Transcription Factor EB Antibody (YA5876) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transcription Factor EB.

HY-P83521A

	Transcription Factor EB Antibody (YA3266)(PBS only) TFEB; BHLHE35; transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Transcription Factor EB Antibody (YA3266) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transcription Factor EB.

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製品番号	製品名		Classification

HY-148230

TFEB Decoy ODN sodium		Decoy ODNs
TFEB Decoy ODN sodium is a synthetic oligonucleotide with a hairpin ring structure, which were designed to inhibit Transcription factor EB (TFEB). TFEB decoy ODN inhibited fibrosis and autophagy in a UUO mouse model. The TFEB decoy ODNs also showed anti-inflammatory effects.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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