1361198-80-2
Chemical Structure
NEO214
- CAS No.: 1361198-80-2
- Formula:C27H35NO5
- Molecular Weight:453.57
IUPAC Name: ((S)-4-(prop-1-en-2-yl)cyclohex-1-en-1-yl)methyl 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate
InChIKey: JDWAOYHBJSFPSD-PSDZMVHGSA-N
SMILES: O=C(N1C(CC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1)=O)OCC4=CC[C@@H](C(C)=C)CC4
Biological Activity: NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NEO214 | 98.0% | NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma. | ||||||||||||||||||||
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Keywords
