54706-99-9
Chemical Structure
20-Deoxyingenol
- No. CAS: 54706-99-9
- Formula:C20H28O4
- Molecular Weight:332.43
IUPAC Name: (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a,6-trihydroxy-1,1,4,7,9-pentamethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one
InChIKey: FOSYZKSOJUQLTD-NHPMXQBPSA-N
SMILES: O=C1[C@@]2(C=C(C)[C@@H]3O)[C@]3(O)[C@H](O)C(C)=C[C@@]1([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]2C
Biological Activity: 20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA)[1][2].
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20-Deoxyingenol | 98.74% | 20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA). | ||||||||||||||||||||
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References
- [1]. Uemura D, et, al. Isolation and structures of 20-deoxyingenol new diterpene, derivatives and ingenol derivative obtained from “kansui”. Tetrahedron Letters. 1974; 15(29): 2527-2528.
- [2]. Gu M, et, al. 20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes. Pharmacol Res. 2021 Jan 15;165:105361. [Content Brief]
