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triazole linker

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128945
    CL2A

    		ADC Linker Inflammation/Immunology Cancer
    CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .
    CL2A
  • HY-174304
    Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide

    		Drug-Linker Conjugates for ADC Cancer
    Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide is a drug-linker conjugates for ADC. Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide consists of Triptolide (HY-32735) and a stable cleavable linker (Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-Cl) (HY-174810). Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide can be used for the synthesis of antibody-drug conjugates (ADCs) .
    Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide
  • HY-W096079
    BCN-endo-PEG4-NHS

    		ADC Linker Cancer
    BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units. BCN-endo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand endo-BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    BCN-endo-PEG4-NHS
  • HY-156311
    BCN-endo-PEG2-maleimide

    		ADC Linker Cancer
    BCN-endo-PEG2-maleimide is an ADC Linker containing 4 PEG units. BCN-endo-PEG2-maleimide contains the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
    BCN-endo-PEG2-maleimide
  • HY-134734
    BCN-exo-PEG7-maleimide

    		ADC Linker Cancer
    BCN-exo-PEG7-maleimide is an ADC Linker containing 7 PEG units. BCN-exo-PEG7-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
    BCN-exo-PEG7-maleimide
  • HY-156322
    BCN-exo-PEG3-maleimide

    		ADC Linker Cancer
    BCN-exo-PEG3-maleimide is an ADC Linker containing 3 PEG units. BCN-exo-PEG3-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which enables the further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
    BCN-exo-PEG3-maleimide
  • HY-156320
    BCN-exo-PEG2-maleimide

    		ADC Linker Cancer
    BCN-exo-PEG2-maleimide is an ADC Linker containing 2 PEG units. BCN-exo-PEG2-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
    BCN-exo-PEG2-maleimide
  • HY-N7497
    Protoescigenin

    		Others Others
    Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .
    Protoescigenin
  • HY-W598198
    Ethyl 3-azidopropanoate

    		Biochemical Assay Reagents Others
    Ethyl 3-azidopropanoate comprises an ethyl ester and a terminal azide group with a 2-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.
    Ethyl 3-azidopropanoate
  • HY-W190926
    2, 5-Dioxo-1-pyrrolidinyl 11-azidoundecanoate

    		Biochemical Assay Reagents Others
    2,5 -Dioxo-1-pyrrolidinyl 11-azidoundecanoate is a linker containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
    2, 5-Dioxo-1-pyrrolidinyl 11-azidoundecanoate
  • HY-156317
    BCN-endo-PEG7-maleimide

    		ADC Linker Cancer
    BCN-endo-PEG7-maleimide is an ADC Linker containing 7 PEG units. BCN-endo-PEG7-maleimide contains the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    BCN-endo-PEG7-maleimide
  • HY-W190881
    N3-PEG11-CH2CH2Br

    		Biochemical Assay Reagents Others
    N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.
    N3-PEG11-CH2CH2Br
  • HY-161943
    NEU3-IN-1

    		Influenza Virus Neurological Disease
    NEU3-IN-1 (compound 963) is a NEU3 inhibitor (Ki: 0.12 μM; IC50: 0.31 μM) based on the 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) scaffold and is a C9 biphenylcarbamate derivative. NEU is a human neuraminidase with 4 isozymes; NEU3-IN-1 is an important tool for studying the function of NEU3 isozymes; its amide and triazole linker analogs are selective for NEU1 and NEU4 isozymes, respectively .
    NEU3-IN-1
  • HY-151647
    3-Azidopropanoic acid-PFP ester

    		Biochemical Assay Reagents Others
    3-Azidopropanoic acid-PFP ester is an azidopropanoic acid linker that contains an activated PFP ester. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole linkages. The activated PFP ester can react with amine groups to form stable amide bonds . 3-Azidopropanoic acid-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3-Azidopropanoic acid-PFP ester
  • HY-174810
    Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-Cl

    		ADC Linker Cancer
    Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-Cl is a cleavable and silyl ether-based ADC linker that can be used in the synthesis of antibody-drug conjugates (ADC) .
    Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-Cl
  • HY-128945A
    CL2A TFA

    		ADC Linker Inflammation/Immunology Cancer
    CL2A TFA is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A TFA is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .
    CL2A TFA
  • HY-155791
    SMCC-NH-CH2-triazole-PEG8-oxydiacetamide-Lys(MTT)-PAB

    		ADC Linker Cancer
    SMCC-NH-CH2-triazole-PEG8-oxydiacetamide-Lys(MTT)-PAB (Page 7, Compound C) is an ADC linker that can be used for the synthesis of antibody-conjugated active molecules (ADC) .
    SMCC-NH-CH2-triazole-PEG8-oxydiacetamide-Lys(MTT)-PAB
  • HY-D2756
    OG 488 alkyne

    		Fluorescent Dye Others
    OG 488 alkyne is a bright, green-fluorescent alkyne-activated probe routinely used for imaging of azide-containing biomolecules. OG 488 Alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker.
    OG 488 alkyne
  • HY-156323
    BCN-exo-PEG4-NHS

    		ADC Linker Cancer
    BCN-exo-PEG4-NHS is an ADC Linker containing 4 PEG units. BCN-exo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    BCN-exo-PEG4-NHS
  • HY-156324
    BCN-exo-PEG8-NHS

    		ADC Linker Cancer
    BCN-exo-PEG8-NHS is an ADC Linker containing 8 PEG units. BCN-exo-PEG8-NHS contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    BCN-exo-PEG8-NHS
  • HY-156319
    BCN-exo-PEG2-NH2

    		ADC Linker Cancer
    BCN-exo-PEG2-NH2 is an ADC Linker containing 2 PEG units. BCN-exo-PEG2-NH2 contains the lyophilic bidentate macrocyclic ligand BCN, which can further synthesize macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    BCN-exo-PEG2-NH2
  • HY-156310
    BCN-endo-PEG7-NH2

    		ADC Linker Cancer
    BCN-endo-PEG7-NH2 is an ADC Linker containing 7 PEG units. BCN-endo-PEG7-NH2 contains the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    BCN-endo-PEG7-NH2
  • HY-180121
    tBu-MTX-CO-NH-C2-O-C2-N3

    		Drug Intermediate Others
    tBu-MTX-CO-NH-C2-O-C2-N3 (Compound 4a) is an azide compound, which can be used as a drug intermediate for the construction of chemical inducers of dimerisation.
    tBu-MTX-CO-NH-C2-O-C2-N3
  • HY-126677
    Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA

    		ADC Linker PROTAC Linkers Cancer
    Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-agent-conjugation (ADC). Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA also is a PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA
  • HY-163789
    Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide

    		ADC Linker Cancer
    Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
    Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide
  • HY-W800671
    1,5-Diazidopentane

    1,5-Pentane diazide

    		 Biochemical Assay Reagents Others
    1,5-Diazidopentane (1,5-Pentane diazide) is a linker with two azide groups which can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
    1,5-Diazidopentane
  • HY-W800704
    BP Fluor 594 alkyne

    		Fluorescent Dye Others
    BP Fluor 594 alkyne is a bright, red-fluorescent alkyne-activated probe routinely used for imaging of azide-containing biomolecules. BP Fluor 594 alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker.
    BP Fluor 594 alkyne
  • HY-W096068
    Propargyl-PEG4-mesyl ester

    		Biochemical Assay Reagents Others
    Propargyl-PEG5-Ms represents a bifunctional linker possessing a proparygyl group reactive towards azides in copper (I) click chemistry to form stable triazoles with the target compound as well as a mesyl group which is a good leaving group for nucleophilic reactions.
    Propargyl-PEG4-mesyl ester
  • HY-W540023
    endo-BCN-Fmoc-L-Lysine

    		ADC Linker Cancer
    Endo-BCN-Fmoc-L-Lysine is a linker containing the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
    endo-BCN-Fmoc-L-Lysine
  • HY-W800657
    Azido-PEG1-hydrazide hydrochloride

    		Biochemical Assay Reagents Others
    Azido-PEG1-hydrazide hydrochloride is a bifunctional PEG linker containing an azide group and a hydrazide group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds.
    Azido-PEG1-hydrazide hydrochloride
  • HY-W591964
    t-Boc-aminooxy-pentane-azide

    		Biochemical Assay Reagents Others
    t-Boc-Aminooxy-pentane-azide is a linker containing an azide group and Boc-protected amino group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    t-Boc-aminooxy-pentane-azide
  • HY-W190917
    N1, N4-Bisazidospermine bistosylate

    		Biochemical Assay Reagents Others
    N1, N4-Bisazidospermine bistosylate is a spermine linker containing two azide groups. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.
    N1, N4-Bisazidospermine bistosylate
  • HY-N7497R
    Protoescigenin (Standard)

    		Reference Standards Others Others
    Protoescigenin (Standard) is the analytical standard of Protoescigenin. This product is intended for research and analytical applications. Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .
    Protoescigenin (Standard)
  • HY-W591962
    5-Azidopentan-1-ol

    1-Pentanol, 5-azido-

    		 Biochemical Assay Reagents Others
    5-Azidopentan-1-ol (1-Pentanol, 5-azido-) is a linker containing an azide group and a terminal hydroxyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
    5-Azidopentan-1-ol
  • HY-W800670
    Mal-amido-PEG5-alkyne

    		Biochemical Assay Reagents Others
    Mal-amido-PEG5-alkyne is a PEG linker containing a maleimide group and an alkyne. The hydrophilic PEG spacer increases solubility in aqueous media. The alkyne group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
    Mal-amido-PEG5-alkyne
  • HY-W800698
    BP Fluor 430 alkyne

    		Fluorescent Dye Others
    BP Fluor 430 Alkyne is a green-fluorescent alkyne-activated probe routinely used for imaging of moderate to high abundance azide-containing biomolecules. BP Fluor 430 Alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker. BP Fluor 430 is a bright, photostable, green-fluorescent probe optimally excited near 430 nm. This probe is water-soluble and its fluorescence is pH independent over a wide pH range.
    BP Fluor 430 alkyne
  • HY-169368
    Thalidomide-O-Triazole-C4-amino

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-O-Triazole-C4-amino is an E3 ligase ligand-linker conjugate. Thalidomide-O-Triazole-C4-amino can be used to synthesize aTAG 4531 (HY-163168) .
    Thalidomide-O-Triazole-C4-amino
  • HY-W590592
    Azido-PEG12-azide

    		Biochemical Assay Reagents Others
    Azido-PEG12-azide is a monodisperse PEG linker containing two azide groups. The azide group can react with alkyne, BCN, or DBCO via Click Chemistry to yield a stable triazole linkage.
    Azido-PEG12-azide
  • HY-181058
    Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC

    		Drug-Linker Conjugates for ADC Cancer
    Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC is a drug-linker conjugate, with Cyclopamine (HY-17024) as its drug moiety. Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC itself exhibits no significant anti-tumor activity. Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC can be used for the synthesis of ADC molecules .
    Cyclopamine-COO-2-ethoxy-1,3-benzodioxole-O-C-Triazole-C5-AC
  • HY-W590575
    Azido-PEG3-flouride

    		Biochemical Assay Reagents Others
    Azido-PEG3-flouride is a PEG linker containing a fluorine atom and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
    Azido-PEG3-flouride
  • HY-W197430
    Ethyl 6-azidohexanoate

    		Biochemical Assay Reagents Others
    Ethyl 6-azidohexanoate comprises an ethyl ester and a terminal azide group with a 5-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.
    Ethyl 6-azidohexanoate
  • HY-W598199
    Ethyl 4-azidobutyrate

    		Biochemical Assay Reagents Others
    Ethyl 4-azidobutyrate comprises an ethyl ester and a terminal azide group with a 3-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.
    Ethyl 4-azidobutyrate
  • HY-W190928
    2-(Azido-PEG2-amido)-1,3-bis-(tert-butyldimethylsilanoxy)propane

    		Biochemical Assay Reagents Others
    2-(Azido-PEG2-amido)-1,3-bis-(tert-butyldimethylsilanoxy)propane is a PEG linker containing a TBDMS acid labile, alcohol protecting group. The azide group is able to participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to generate triazole linkages. The hydrophilic PEG linker increases the solubility properties of compounds in aqueous media.
    2-(Azido-PEG2-amido)-1,3-bis-(tert-butyldimethylsilanoxy)propane
  • HY-W591963
    5-Azidopentyl 4-methylbenzenesulfonate

    Tos-pentane-azide

    		 Biochemical Assay Reagents Others
    5-Azidopentyl 4-methylbenzenesulfonate (Tos-pentane-azide) is a linker containing an azide group and a tosyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions.
    5-Azidopentyl 4-methylbenzenesulfonate
  • HY-W591360
    Iodoacetamido-PEG6-azide

    		Biochemical Assay Reagents Others
    Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
    Iodoacetamido-PEG6-azide
  • HY-W454989
    Hept-6-yn-1-yl 4-methylbenzenesulfonate

    		Biochemical Assay Reagents Others
    Hept-6-yn-1-yl 4-methylbenzenesulfonate is a linker containing a tosyl group and a propargyl group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
    Hept-6-yn-1-yl 4-methylbenzenesulfonate
  • HY-W800706
    Azidobutanamide-tri-(carboxyethoxymethyl)-methane

    		Biochemical Assay Reagents Others
    Azidobutanamide-tri-(carboxyethoxymethyl)-methane is a aqueous soluble PEG linker with an azide group with three terminal carboxylic acids. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    Azidobutanamide-tri-(carboxyethoxymethyl)-methane
  • HY-W800664
    5-(Azido-PEG4)-pent-2-yn-1-ol

    		Biochemical Assay Reagents Others
    5-(Azido-PEG4)-pent-2-yn-1-Ol is a PEG linker containing an azide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
    5-(Azido-PEG4)-pent-2-yn-1-ol
  • HY-W800694
    BP Fluor 405 alkyne triTEA

    		Fluorescent Dye Others
    BP Fluor 405 alkyne triTEA is a blue-fluorescent dye that often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 alkyne triTEA reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker. A probe for copper-less detection (BP Fluor 405 DBCO) is also available for application where the presence of copper is not acceptable.
    BP Fluor 405 alkyne triTEA

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