3-Azidopropanoic acid-PFP ester

Cat. No.: HY-151647 Purity: 95.70%: Data Sheet
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3-Azidopropanoic acid-PFP ester is an azidopropanoic acid linker that contains an activated PFP ester. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole linkages. The activated PFP ester can react with amine groups to form stable amide bonds. 3-Azidopropanoic acid-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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3-Azidopropanoic acid-PFP ester Chemical Structure

CAS No. : 1240801-10-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Based on 1 publication(s) in Google Scholar

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Description

3-Azidopropanoic acid-PFP ester is an azidopropanoic acid linker that contains an activated PFP ester. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole linkages. The activated PFP ester can react with amine groups to form stable amide bonds^[1]. 3-Azidopropanoic acid-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Molecular Weight

281.14

Formula

C₉H₄F₅N₃O₂

CAS No.

1240801-10-8

Appearance

Solid

Color

White to off-white

SMILES

[N-]=[N+]=NCCC(OC1=C(F)C(F)=C(F)C(F)=C1F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (355.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5569 mL	17.7847 mL	35.5695 mL
5 mM	0.7114 mL	3.5569 mL	7.1139 mL
10 mM	0.3557 mL	1.7785 mL	3.5569 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.70%

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Data Sheet (268 KB) SDS (251 KB)

COA (245 KB) HNMR (245 KB) RP-HPLC (252 KB)

Handling Instructions (2659 KB)

References

[1]. Fiehn T, et al. A cyclopeptide-derived molecular cage for sulfate ions that closes with a click. Chemistry. 2010 Jun 25;16(24):7241-55. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5569 mL	17.7847 mL	35.5695 mL	88.9237 mL
	5 mM	0.7114 mL	3.5569 mL	7.1139 mL	17.7847 mL
	10 mM	0.3557 mL	1.7785 mL	3.5569 mL	8.8924 mL
	15 mM	0.2371 mL	1.1856 mL	2.3713 mL	5.9282 mL
	20 mM	0.1778 mL	0.8892 mL	1.7785 mL	4.4462 mL
	25 mM	0.1423 mL	0.7114 mL	1.4228 mL	3.5569 mL
	30 mM	0.1186 mL	0.5928 mL	1.1856 mL	2.9641 mL
	40 mM	0.0889 mL	0.4446 mL	0.8892 mL	2.2231 mL
	50 mM	0.0711 mL	0.3557 mL	0.7114 mL	1.7785 mL
	60 mM	0.0593 mL	0.2964 mL	0.5928 mL	1.4821 mL
	80 mM	0.0445 mL	0.2223 mL	0.4446 mL	1.1115 mL
	100 mM	0.0356 mL	0.1778 mL	0.3557 mL	0.8892 mL