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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
ubiquitin-dependent proteasomal activity
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "ubiquitin-dependent proteasomal activity" in MCE Product Catalog:
Cat. No.: HY-151886
CAS No.: 2759420-43-2
Research Areas:
NU223612 is a cereblon (CRBN)-recruiting IDO1 PROTAC degrader, with a DC50 value of 0.329-0.5438 μM against human IDO1, and it is capable of penetrating the blood-brain barrier. NU223612 directly binds to IDO1, mediates the degradation of both wild-type and catalytically inactive mutant IDO1 proteins, and does not degrade TDO2. NU223612 inhibits IDO1-mediated enzymatic activity. NU223612 directly binds to CRBN and promotes the formation of a cooperative ternary complex with IDO1. NU223612 induces ubiquitin-dependent proteasomal degradation of the IDO1 protein. NU223612 suppresses IDO1-mediated non-enzymatic phosphorylation of NF-κB p65 and the DNA-binding activity of downstream transcription factors. NU223612 can be used in studies of glioblastoma (malignant glioma) .
Cat. No.: HY-164807
CAS No.: 1489236-55-6
Target:
Research Areas:
SARD279 is a HyT degrader of androgen receptor (AR). SARD279 binds to AR, recruits HSP70, mediates ubiquitin-dependent proteasomal degradation, and competitively inhibits the transactivation of AR. SARD279 exhibits antiproliferative activity in AR-dependent prostate cancer cells and castration-resistant prostate cancer cells, including those harboring the AR F876L mutation. SARD279 can be used in studies related to prostate cancer and castration-resistant prostate cancer .
Cat. No.: HY-173009
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PROTAC CG167 is a selective bifunctional PROTAC degrader targeting CypA, with a DC50 of 123 nM. PROTAC CG167 drives ubiquitin-dependent and ubiquitin-like modification-dependent proteasomal degradation of CypA by recruiting the VHL E3 ligase complex. PROTAC CG167 exhibits anti-HIV‑1 and anti-HCV replication activities, and selectively reduces CypA levels in various cells. PROTAC CG167 can be used in studies related to viral infections .
Cat. No.: HY-P12182
Target:
Research Areas:
Mca-KKVAPYPME-Dap(Dnp)-NH2 is a fluorescent peptide substrate. Mca-KKVAPYPME-Dap(Dnp)-NH2 can be used to report ATP-dependent protease activities, such as those of the 26S Proteasome or ClpP protease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
