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Cat. No.: HY-P12182

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Mca-KKVAPYPME-Dap(Dnp)-NH2

Mca-KKVAPYPME-Dap(Dnp)-NH2 is a fluorescent peptide substrate. Mca-KKVAPYPME-Dap(Dnp)-NH2 can be used to report ATP-dependent protease activities, such as those of the 26S Proteasome or ClpP protease.

For research use only. We do not sell to patients.

Formula: C₇₀H₉₆N₁₆O₂₁S
Molecular Weight:1529.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mca-KKVAPYPME-Dap(Dnp)-NH2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Mca-KKVAPYPME-Dap (Dnp)-NH₂ serves as a substrate for proteasome activity assays and proteasome assembly experiments^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1529.67
Formula C₇₀H₉₆N₁₆O₂₁S
SMILES

O=C(N[C@H](C(N)=O)CNC1=C(C=C(C=C1)[N+]([O-])=O)[N+]([O-])=O)[C@@H](NC([C@H](CCSC)NC([C@H]2N(C([C@H](CC3=CC=C(O)C=C3)NC([C@H]4N(C([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC(CC(C5=CC=C(OC)C=C5O6)=CC6=O)=O)=O)=O)=O)=O)CCC4)=O)=O)CCC2)=O)=O)CCC(O)=O
Sequence

{Mca}-Lys-Lys-Val-Ala-Pro-Tyr-Pro-Met-Glu-{Dap(Dnp)}-NH2
Sequence Shortening

{Mca}-KKVAPYPME-{Dap(Dnp)}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guo X, et al. Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice. bioRxiv [Preprint]. 2024 Sep 14:2024.09.10.612226.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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