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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
uremic
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "uremic" in MCE Product Catalog:
13
13 Publications Verification
Synonyms: LNP023
Target:
Research Areas:
Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
13
13 Publications Verification
Synonyms: LNP023 hydrochloride
Target:
Research Areas:
Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
6
6 Cited Publications
Synonyms: p-Tolyl sulfate
Target:
6
6 Cited Publications
Synonyms: p-Tolyl sulfate potassium
Category:
Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
5
Target:
Research Areas:
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
1
1 Cited Publications
Cat. No.: HY-W011910
CAS No.: 2642-37-7
1
Category:
Ketones, Aldehydes, Acids Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
Target:
1
1 Cited Publications
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Research Areas:
Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
Category:
Alkaloids Other disease Disease markers Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-P99365
CAS No.: 1803171-55-2
Synonyms: ALXN1210
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Research Areas:
Category:
Alkaloids Leguminosae Other Diseases Plants Disease Research Fields Indigofera Indole Alkaloids
Target:
Cat. No.: HY-P99050
CAS No.: 2049079-64-1
Synonyms: BIVV009; IPN-009; TNT009
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Research Areas:
Target:
Research Areas:
Pramocaine (Pramoxine) hydrochloride is a topical surface anesthetic and antipruritic agent. Pramocaine hydrochloride reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine hydrochloride can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain .
Synonyms: p-Tolyl sulfate-d7 potassium
Cat. No.: HY-W416250
CAS No.: 17680-99-8
Target:
Cat. No.: HY-W674241A
Cat. No.: HY-113432R
CAS No.: 701-44-0
Synonyms: 2PY (Standard)
Category:
Cat. No.: HY-111431AR
CAS No.: 91978-69-7
Synonyms: p-Tolyl sulfate potassium (Standard)
Cat. No.: HY-W014130R
CAS No.: 155-84-0
Synonyms: Ac-Arg-OH (Standard)
Cat. No.: HY-200854
CAS No.: 2447007-60-3
Synonyms: LNP023 hydrochloride hydrate
Target:
Research Areas:
Iptacopan (LNP023) hydrochloride hydrate is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride hydrate exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride hydrate can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
