2. Stem Cell/Wnt
  3. YAP
  4. VT104

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.

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CAS 番号 : 2417718-25-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 在庫あり
Solution
10 mM * 1 mL in DMSO USD 132 在庫あり
Solid
1 mg $90 在庫あり
5 mg $120 在庫あり
10 mg $200 在庫あり
25 mg $440 在庫あり
50 mg $690 在庫あり
100 mg $970 在庫あり
250 mg $1460 在庫あり
500 mg $2100 在庫あり
1 g $2950 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of VT104:

VT104 関連抗体

Top Publications Citing Use of Products

    VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.

    Dose response curves of VT104 (0.001-10 μM) in SCEACono2 (ONO2) cells examined in proliferation assay and clonogenic assay.

    VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.

    qPCR for YAP/TAZ-TEAD target genes upon treatment with VT104 (1 µM) for 24 hours in ONO2 cells in vitro (n=3).

    VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.

    YAP co-immunoprecipitation experiment in ONO2 cells treated with VT104 (1µM) for 24 hours.

    YAP アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    NCI-H226 IC50
    0.042 μM
    Compound: VT-104
    Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
    Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
    		[PMID: 35763499]
    体外実験

    VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    VT104 関連抗体
    体内実験

    VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NCI-H226-tumor bearing mice[1]
    Dosage: 0.3, 1, and 3 mg/kg
    Administration: Oral administration
    Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner.
    分子量

    420.43

    分子式

    C25H19F3N2O
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC=CC=C4)C
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (237.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3785 mL 11.8926 mL 23.7852 mL
    5 mM 0.4757 mL 2.3785 mL 4.7570 mL
    10 mM 0.2379 mL 1.1893 mL 2.3785 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

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    一般には略語で表示されます：C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    純度とドキュメンテーション

    純度: 99.94%

    COA (252 KB) LCMS (93 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3785 mL 11.8926 mL 23.7852 mL 59.4629 mL
    5 mM 0.4757 mL 2.3785 mL 4.7570 mL 11.8926 mL
    10 mM 0.2379 mL 1.1893 mL 2.3785 mL 5.9463 mL
    15 mM 0.1586 mL 0.7928 mL 1.5857 mL 3.9642 mL
    20 mM 0.1189 mL 0.5946 mL 1.1893 mL 2.9731 mL
    25 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3785 mL
    30 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
    40 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4866 mL
    50 mM 0.0476 mL 0.2379 mL 0.4757 mL 1.1893 mL
    60 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL
    80 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.7433 mL
    100 mM 0.0238 mL 0.1189 mL 0.2379 mL 0.5946 mL
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    VT104 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    VT1042417718-25-1VT 104VT-104YAPYes-associated proteinTEAD1TEAD3palmitoylationcancarInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-134956
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