2,5-Diphenyloxazole
Based on 1 Customer Validation
2,5-Diphenyloxazole (PPO; DPO; POP) is a fluorescent dye, as well as a substrate and metabolite precursor of cytochrome P-450 (cytochrome P-448/P1-450). 2,5-Diphenyloxazole serves as a scintillator.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 92-71-7
- Formula: C15H11NO
- Molecular Weight:221.26
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
2,5-Diphenyloxazole (PPO; DPO; POP) (293 K, 78 K) embedded in plastic scintillator EJ-276 exhibits a first excited singlet state lifetime of 1.25 ns at 293 K and a two-component triplet state phosphorescence decay (3.61 ms and 0.63 ms) at 78 K, with photophysical properties not substantially altered compared to solvent-based DPO[1].
2,5-Diphenyloxazole (PPO; DPO; POP) (90 nM; 30 min) metabolism by phytohaemagglutinin-stimulated human peripheral lymphocytes correlates strongly (r=0.95) with benzo(a)pyrene hydroxylase activity, and benzanthracene-induced 2,5-Diphenyloxazole metabolism in these cells is inhibited by α-naphthoflavone and high concentrations of SKF 525A but not metyrapone[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 92-71-7
-
Appearance Solid
-
Molecular Weight 221.26
-
Formula C15H11NO
-
Color White to off-white
-
SMILES
C1(C2=CC=CC=C2)=NC=C(C3=CC=CC=C3)O1
-
Synonyms
PPO; DPO; POP
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (564.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5196 mL | 22.5978 mL | 45.1957 mL | 112.9892 mL |
| 5 mM | 0.9039 mL | 4.5196 mL | 9.0391 mL | 22.5978 mL | |
| 10 mM | 0.4520 mL | 2.2598 mL | 4.5196 mL | 11.2989 mL | |
| 15 mM | 0.3013 mL | 1.5065 mL | 3.0130 mL | 7.5326 mL | |
| 20 mM | 0.2260 mL | 1.1299 mL | 2.2598 mL | 5.6495 mL | |
| 25 mM | 0.1808 mL | 0.9039 mL | 1.8078 mL | 4.5196 mL | |
| 30 mM | 0.1507 mL | 0.7533 mL | 1.5065 mL | 3.7663 mL | |
| 40 mM | 0.1130 mL | 0.5649 mL | 1.1299 mL | 2.8247 mL | |
| 50 mM | 0.0904 mL | 0.4520 mL | 0.9039 mL | 2.2598 mL | |
| 60 mM | 0.0753 mL | 0.3766 mL | 0.7533 mL | 1.8832 mL | |
| 80 mM | 0.0565 mL | 0.2825 mL | 0.5649 mL | 1.4124 mL | |
| 100 mM | 0.0452 mL | 0.2260 mL | 0.4520 mL | 1.1299 mL |
2,5-Diphenyloxazole Related Classifications
HY-W014018 Related Classifications
Powered by Bioz
- 2,5-Diphenyloxazole
- 92-71-7
- PPO
- DPO
- POP
- Fluorescent Dye
- metyrapone
- cytochrome P-450
- phytohaemagglutinin-stimulated human peripheral lymphocytes
- α-naphthoflavone
- benzo(a)pyrene hydroxylase
- 3-methylcholanthrene
- SKF 525A
- cytochrome P-448/P1-450
- aryl hydrocarbon hydroxylase
- human lymphocytes
- Inhibitor
- inhibitor
- inhibit