1. GPCR/G Protein
  2. Adenosine Receptor

2-Cl-IB-MECA (Synonyms: Chloro-IB-MECA; CF-102; CI-IB-MECA; Namodenoson)

Cat. No.: HY-12365 Purity: 99.51%
Handling Instructions

2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM).

For research use only. We do not sell to patients.

2-Cl-IB-MECA Chemical Structure

2-Cl-IB-MECA Chemical Structure

CAS No. : 163042-96-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 201 In-stock
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Estimated Time of Arrival: December 31
2 mg USD 84 In-stock
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Estimated Time of Arrival: December 31
5 mg USD 168 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 288 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 540 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 780 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. target: A3 adenosine receptor agonist;[1] Ki:0.33 nM;[2] In vitro: In human ADF cells of astroglial lineage, 100 nM Cl-IB-MECA caused a marked reorganization of the cytoskeleton, with appearance of stress fibres and numerous cell protrusions. High concentrations of Cl-IB-MECA directly cause influx of Ca2+.[2] In vivo: Intravenous administration of 200 μg/kg 2-Cl-IB-MECA resulted in a short-lasting hypotension, which was accompanied by a 50–100-fold increase in plasma histamine concentrations. Administration of a second dose of 2-Cl-IB-MECA did not elicit any hemodynamic effects. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8358 mL 9.1789 mL 18.3577 mL
5 mM 0.3672 mL 1.8358 mL 3.6715 mL
10 mM 0.1836 mL 0.9179 mL 1.8358 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

544.73

Formula

C₁₈H₁₈ClIN₆O₄

CAS No.

163042-96-4

SMILES

O[[email protected]]([[email protected]@H]1O)[[email protected]@H](O[[email protected]@H]1C(NC)=O)N2C3=NC(Cl)=NC(NCC4=CC(I)=CC=C4)=C3N=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
2-Cl-IB-MECA
Cat. No.:
HY-12365
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