1. GPCR/G Protein
  2. Adenosine Receptor
  3. Regadenoson

Regadenoson (Synonyms: CVT-3146)

Cat. No.: HY-A0168 Purity: 99.59%
Handling Instructions

Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents.

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Regadenoson Chemical Structure

Regadenoson Chemical Structure

CAS No. : 313348-27-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 93 In-stock
Estimated Time of Arrival: December 31
2 mg USD 60 In-stock
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5 mg USD 108 In-stock
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10 mg USD 168 In-stock
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25 mg USD 228 In-stock
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50 mg USD 348 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents[1][2][3].

Clinical Trial
Molecular Weight

390.35

Formula

C₁₅H₁₈N₈O₅

CAS No.

313348-27-5

SMILES

OC[[email protected]@H]1[[email protected]]([[email protected]]([[email protected]](N2C=NC3=C2N=C(N4N=CC(C(NC)=O)=C4)N=C3N)O1)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (128.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5618 mL 12.8090 mL 25.6180 mL
5 mM 0.5124 mL 2.5618 mL 5.1236 mL
10 mM 0.2562 mL 1.2809 mL 2.5618 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RegadenosonCVT-3146CVT3146CVT 3146Adenosine ReceptorP1 receptorvasodilatorstressagentmyocardialperfusionimagingselectiveInhibitorinhibitorinhibit

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Regadenoson
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