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Cat. No.: HY-N7573

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2-Deacetoxy-taxinine J

2-Deacetoxy-taxinine J is a Diterpenoids product that can be isolated from the heartwoods of Taxus cuspidata..

For research use only. We do not sell to patients.

CAS No.: 119347-14-7
Formula: C₃₇H₄₆O₁₀
Molecular Weight:650.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (242 KB)

2-Deacetoxy-taxinine J Chemical Structure

CAS No.: 119347-14-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Biological Activity

Description

2-Deacetoxy-taxinine J is a Diterpenoids product that can be isolated from the heartwoods of Taxus cuspidata.^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	9.7 μM Compound: 2	Antiproliferative activity against human A2780 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A2780 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
A549	IC₅₀	7.1 μM Compound: 2	Antiproliferative activity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
A549	IC₅₀	9.4 μM Compound: 2	Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
HCT-8	IC₅₀	11 μM Compound: 2	Antiproliferative activity against human HCT8 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HCT8 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
HEK293	IC₅₀	>50 μM Compound: 1, 2-DAT-J	Cytotoxicity against HEK293 cells after 18 hrs by MTT assay Cytotoxicity against HEK293 cells after 18 hrs by MTT assay	[PMID: 19446930]
HeLa	IC₅₀	5.7 μM Compound: 12	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 dye based assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 dye based assay	[PMID: 28240909]
HepG2	IC₅₀	>25 μM Compound: 2	Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
KB	ED₅₀	4.8 μg/mL Compound: 10	Cytotoxic activity of compound was evaluated against KB cell line. Cytotoxic activity of compound was evaluated against KB cell line.	[PMID: 12217376]
KB	IC₅₀	>10 μg/mL Compound: 27	Cytotoxicity against human epidermoid carcinoma KB cells Cytotoxicity against human epidermoid carcinoma KB cells	10.1016/S0960-894X(97)00029-2
KB 3-1	ED₅₀	3.5 μg/mL Compound: 10	Cytotoxic activity of compound was evaluated against drug resistant subline KB-7d cells Cytotoxic activity of compound was evaluated against drug resistant subline KB-7d cells	[PMID: 12217376]
L1210	IC₅₀	4.9 μg/mL Compound: 27	Cytotoxicity against murine leukemia L1210 cells Cytotoxicity against murine leukemia L1210 cells	10.1016/S0960-894X(97)00029-2
MCF7	IC₅₀	>25 μM Compound: 2	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
MCF7	IC₅₀	20 μM Compound: 1, 2-DAT-J	Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay	[PMID: 19446930]
MDA-MB-231	IC₅₀	10 μM Compound: 1, 2-DAT-J	Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay	[PMID: 19446930]
NIH3T3	IC₅₀	15 μM Compound: 2	Antiproliferative activity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
SW480	IC₅₀	>25 μM Compound: 2	Antiproliferative activity against human SW480 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human SW480 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]

Chemical Information

CAS No. 119347-14-7
Molecular Weight 650.76
Formula C₃₇H₄₆O₁₀
SMILES

C[C@]([C@](C1=C)([H])C[C@@](C[C@@H]2OC(C)=O)([H])C3(C)C)([C@H](C[C@@H]1OC(/C=C/C4=CC=CC=C4)=O)OC(C)=O)[C@H]([C@@H](C3=C2C)OC(C)=O)OC(C)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.