Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis

  • Bioorg Med Chem Lett. 2002 Oct 7;12(19):2785-8. doi: 10.1016/s0960-894x(02)00528-0.
Youichi Shinozaki  1 ,  Narihiko Fukamiya ,  Chieko Uchiyama ,  Masayoshi Okano ,  Kiyoshi Tagahara ,  Kenneth F Bastow ,  Kuo-Hsiung Lee
Affiliations
  • 1. Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
PMID: 12217376 DOI: 10.1016/s0960-894x(02)00528-0
Abstract

Twelve taxane diterpenes (1-12), which were isolated previously from the EtOH extract of the aerial parts of Taxus yunnanensis or Taxus chinensis, were evaluated for cytotoxicity against the multidrug resistant Cancer cells KB-VIN and KB-7d. Compounds and showed significant cytotoxicity in these cell lines. Compounds and also demonstrated significant activity against KB-7d. The biflavonoid isolated from T. yunnanensis was only marginally cytotoxic against the A549 (lung) cell line, but a simple methoxylated analogue (14) was inactive.