3-Heptadecylcatechol
3-Heptadecylcatechol is an urushiphenol compound found in Toxicodendron vernicifluum resin and poison oak urushiol. 3-Heptadecylcatechol exhibits anti-platelet aggregation and immune regulation activity. 3-Heptadecylcatechol can be used for the research of thrombotic disorders.
For research use only. We do not sell to patients.
- CAS No.: 5862-27-1
- Formula: C23H40O2
- Molecular Weight:348.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
3-Heptadecylcatechol (5 min) inhibits ADP-induced rabbit platelet aggregation with an IC50 of 7.67 μmol/L and AA-induced rabbit platelet aggregation with an IC50 of 6.04 μmol/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice (male or female, 6-10 weeks)[2]
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Dosage:2.5 mg (abdominal cutaneous application); 50 μg (ear cutaneous application)
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Administration:cutaneous application; single dose
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Result:Induced draining inguinal lymph node cell (LNC) proliferation that peaked 5-6 days post-abdominal treatment, while distal cervical LNC showed minimal proliferation.
Induced cervical LNC proliferation that peaked 5 days post-ear treatment; prior abdominal sensitization strongly suppressed this cervical LNC proliferation.
Induced suppressive activity against recipient LNC proliferation starting 7 days post-sensitization, with up to 58% suppression observed 10 days post-sensitization.
Showed both specific and non-specific components: suppression of homologous-induced proliferation was significantly stronger than suppression of OX-induced proliferation.
Completely abrogated suppressive activity when sensitized LNC were treated with anti-Thy-1.2 antibody plus complement, confirming suppressor cells are T lymphocytes.
Did not suppress the in vitro proliferation of optimally activated day-6 sensitized LNC.
Did not affect the induction of contact sensitivity, as ear swelling responses post-challenge were equivalent between recipients of sensitized LNC and normal LNC.
Chemical Information
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CAS No. 5862-27-1
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Molecular Weight 348.56
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Formula C23H40O2
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SMILES
OC1=CC=CC(CCCCCCCCCCCCCCCCC)=C1O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xie Y, et al. New urushiols with platelet aggregation inhibitory activities from resin of Toxicodendron vernicifluum. Fitoterapia. 2016;112:38-44. [Content Brief]
[2]. Dunn IS, et al. Induction of suppressor T cells for lymph node cell proliferation after contact sensitization of mice with a poison oak urushiol component. Immunology. 1984 Apr;51(4):773-81. [Content Brief]
[3]. Dunn IS, et al. Influence of chemical reactivity of urushiol-type haptens on sensitization and the induction of tolerance. Cell Immunol. 1986 Jan;97(1):189-96. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Heptadecylcatechol Related Classifications
HY-N19844 Related Classifications
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