3'OMe-m7GpppAmpG ammonium solution (100 mM) (GMP Like)
3'OMe-m7GpppAmpG ammonium solution (100 mM) (GMP Like) (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100 mM) (GMP Like)) is a GMP-like grade of 3’OMe-m7GpppAmpG. 3’OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) ammonium solution (100 mM) is a trinucleotide Cap1 analog with the structure m7 (3'OMeG)(5') ppp (5')(2'OMeA) pG, and also functions as a cis-acting ligase ribozyme inhibitor. 3’OMe-m7GpppAmpG ammonium solution (100 mM) effectively reduces free 5'-triphosphate groups on RNA transcripts, thereby enabling efficient co-transcriptional capping of in vitro transcribed mRNA. 3’OMe-m7GpppAmpG ammonium solution (100 mM) is not only widely used in the preparation of modified mRNA including trivalent influenza vaccine candidates, but also applicable to studies related to SARS-CoV-2 infection and other relevant research.
For research use only. We do not sell to patients.
- Formula: C33H45N15O24P4·xNH3
- Molecular Weight:1159.69 (free base)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
In Vitro
Chemical Information
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Molecular Weight 1159.69 (free base)
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Formula C33H45N15O24P4·xNH3
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SMILES
O=C1C2=C(N([C@H]3[C@H](O)[C@H](OC)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](OC)[C@@H]4OP(OC[C@H]7O[C@@H](N(C=N8)C9=C8C(NC(N)=N9)=O)[C@H](O)[C@@H]7O)(O)=O)(O)=O)(O)=O)([O-])=O)O3)C=[N+]2C)N=C(N)N1.[x].N
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Synonyms
m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100 mM) (GMP Like)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- 3'OMe-m7GpppAmpG ammonium solution (100 mM) (GMP Like)
- m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100 mM) (GMP Like)
- Nucleoside Antimetabolite/Analog
- SARS-CoV
- SARS-CoV-2 infection
- HA protein
- cis-acting ligase ribozyme
- RNA transcripts
- SARS-CoV-2 spike mRNA
- mRNA
- trivalent influenza vaccine
- HEK293 cells
- LNP formulation
- Inhibitor
- inhibitor
- inhibit