4-Arm-PEG10000-Nitrophenyl carbonate
4-Arm-PEG10000-Nitrophenyl carbonate (4-Arm-PEG10000-NPC) is a four-arm PEG derivative. The core structure of 4-Arm-PEG10000-Nitrophenyl carbonate consists of four PEG chains, each modified at the end with a nitrophenyl carbonate group. 4-Arm-PEG10000-Nitrophenyl carbonate can be used for bioconjugation and drug delivery.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
The structure of PEG-Nitrophenyl carbonate comprises two key parts that work synergistically:
Nitrophenyl carbonate: undergoes a highly efficient nucleophilic substitution reaction with the primary amine groups (-NH2) on molecules such as proteins and peptides, forming stable carbamate bonds.
PEG chain: acts as a hydrophilic spacer, forming a hydration layer on the particle surface, which can reduce non-specific adsorption and recognition and clearance by the immune system, prolonging the circulation time of the carrier in vivo.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
O=C(OOC1=CC=C([N+]([O-])=O)C=C1)OCCOCC(COCCOC(OOC2=CC=C([N+]([O-])=O)C=C2)=O)(COCCOC(OOC3=CC=C([N+]([O-])=O)C=C3)=O)COCCOC(OOC4=CC=C([N+]([O-])=O)C=C4)=O
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Synonyms
4-Arm-PEG10000-NPC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Arm-PEG10000-Nitrophenyl carbonate Related Classifications
HY-W1052829A Related Classifications
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