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Ricolinostat

(Synonyms: ACY-1215; Rocilinostat)
45 Cited Publications
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Based on 45 publication(s) in Google Scholar

Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor, with an IC50 of 5 nM. ACY-1215 also inhibits HDAC1, HDAC2, and HDAC3 with IC50s of 58, 48, and 51 nM, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.83%
  • CAS No.: 1316214-52-4
  • Formula: C24H27N5O3
  • Molecular Weight:433.50
  • Storage:

    4°C, stored under nitrogen

    * In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen)

  • Ricolinostat Chemical Structure
    Ricolinostat Chemical Structure
  • Experimental Validation Results for Ricolinostat
  • Experimental Validation Results for Ricolinostat
  • Experimental Validation Results for Ricolinostat
  • Experimental Validation Results for Ricolinostat
  • Experimental Validation Results for Ricolinostat
  • Experimental Validation Results for Ricolinostat
CAS No.: 1316214-52-4
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[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Ricolinostat Chemical Structure
    Ricolinostat Chemical Structure
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    Ricolinostat purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Jan:109:2464-2471. [Abstract]

    Customer Validation
     The expression of IL-1β and IL-6 in human primary chondrocytes and C28/I2 cells is tested by western blot analysis with the treatment of IL-1β, DMSO and ACY-1215.

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    Ricolinostat purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2019 Jan:109:2464-2471. [Abstract]

    Customer Validation
     The expression of MMP-1, MMP-13 and COL2 A1 in C28/I2 cells is tested by western blot analysis with the treatment of IL-1β, DMSO and ACY-1215.

  • 1/16

    Ricolinostat purchased from MedChemExpress. Usage Cited in: Oncogene. 2018 Nov;37(45):5952-5966. [Abstract]

    Customer Validation
     Mouse CAFs are treated with increasing concentrations of ACY1215 for 24 h. Western blot analysis of tubulin, histone H3, histone H4, acetylated tubulin, acetylated histone H3, and acetylated histone H4.

  • 1/16

    Ricolinostat purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2017 Feb;37(2):1270-1276. [Abstract]

    Customer Validation
     A375 cells are treated with indicated concentrations of ACY-1215. After 72 h, Western blotting assay are utilized to detect apoptosis.

  • 1/16

    Ricolinostat purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2016 Aug 28;379(1):134-142. [Abstract]

    Customer Validation
     Inhibition of HDAC6 by HDAC6-selective inhibitors impairs the proliferation of glioblastoma cells. U87 and U251 cells are treated with HDAC6 selective inhibitors and the cells are harvested for subsequent western blot analysis.

  • 1/16

    Ricolinostat purchased from MedChemExpress. Usage Cited in: Med Oncol. 2016 May;33(5):50. [Abstract]

    Customer Validation
     H460 cells are treated with 0.5 μM Aorafenib and indicated concentration of HDAC6 inhibitors, CAY10603 (CAY, 0.05 μM) or ACY1215 (ACY,1 μM). The cleavage of PARP and caspase 3 also increased after cotreatment.

  • Ricolinostat