Mahonia bealei (Fort.) Carr.
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Mahonia bealei (Fort.) Carr. (1)
Columbamine chloride
Synonyms: Columbamin chloride; Dehydroisocorypalmine chloride
- Formula: C20H20ClNO4
- Molecular Weight: 373.83
Columbamine (Columbamin; Dehydroisocorypalmine) chloride is an organic heterotetracyclic alkaloid extracted from plants. Columbamine chloride is a metabolite of Berberine (HY-N0716). Columbamine chloride inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). Columbamine chloride induces apoptosis in cancer cells. Columbamine chloride can be used for antioxidant, anti-inflammatory, antitumor, antifungal, antiparasite, hepatoprotective, neuroprotective, hypolipidemic and hypoglycemic study.
