Marsdenia tenacissima (Roxb.) Moon

11α-O-Acetyl-12β-O-tigloyl Tenacissoside A is a polyoxypregnane glycoside derived from Marsdenia tenacissima with anti-cancer activity.

Tenacissoside A is an active compound that can be isolated from Marsdenia tenacissima.

Tenacissoside B is an active compound that can be extracted from M. tenacissima.

Tenacissoside E (compound 18) is a polyoxypregnane glycoside.

11α-O-Benzoyl-12β-O-acetyltenacigenin B is a P-glycoprotein (Pgp) inhibitor derived from Marsdenia tenacissima and belongs to the Tenacigenin B (HY-N1168) derivatives. 11α-O-Benzoyl-12β-O-acetyltenacigenin B can inhibit multidrug resistance (MDR) caused by P-glycoprotein (Pgp) overexpression in HepG2/Dox cells and holds potential for research in the field of cancer.

17β-Tenacigenin B is a pregnane genin that can be isolated from XAPI, a traditional anticancer Chinese medicinal formula.

21-Deoxyneridienone B is a Steroids product that can be isolated from the herbs of Marsdenia tenacissima.

Tenacissoside C is an anti-cancer compound that inhibits angiogenesis. Tenacissoside C induces apoptosis in cancer cells by down-regulating the expression of anti-apoptotic factors and activating caspase-9 and caspase-3. Tenacissoside C also causes cell cycle arrest in cancer cells and induces apoptosis through the mitochondrial pathway.

Marsdenoside K is a polyoxygenated pregnane glycoside that can be isolated from Marsdenia tenacissima.

Tenacissimoside J is a steroid glycoside and can be isolated from Marsdenia tenacissima.

Marstenacisside F1 (compound 1) is a polyoxypregnanoside with anti-inflammatory activity isolated from Marsdenia tenacissima. Marstenacisside F1 inhibits lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells and is a derivative of Tenacigenin B.

11α-O-Tigloyl-12β-O-acetyltenacigenin B is an ester derivative of Tenacigenin B (HY-N1168), which is isolated from Garcinia cambogia (MTC). Tenacigenin B modulates the antitumor effects of Aurora-A in lymphoma.