Tabernaemontana bufalina Lour.
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Tabernaemontana bufalina Lour. (2)
19-Hydroxypseudovincadifformine
Cat. No.: HY-N16970
CAS No.: 2340171-73-3
- Formula: C21H26N2O3
- Molecular Weight: 354.44
19-Hydroxypseudovincadifformine is a natural alkaloid.
Hecubine
Cat. No.: HY-N9164
CAS No.: 62874-52-6
- Formula: C20H26N2O
- Molecular Weight: 310.43
Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases.
