62874-52-6
Chemical Structure
Hecubine
- CAS No.: 62874-52-6
- Formula:C20H26N2O
- Molecular Weight:310.43
IUPAC Name: (1aR,3R,13S,13aS)-13-ethyl-10-methyl-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methanooxireno[2',3':9,10][1]azacycloundecino[5,4-b]indole
InChIKey: XUDAGNVXWJRKJD-AQNXPRMDSA-N
SMILES: CC[C@@]12[C@@]3([H])[C@](C[N@](CCC4=C(N(C5=CC=CC=C54)C)CC2)C1)([H])O3
Biological Activity: Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases[1].
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Hecubine | Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases. | |||||||||||||||||||||
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Keywords
