Omadacycline hydrochloride
Based on 33 publication(s) in Google Scholar
Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 1196800-39-1
- Formula: C29H40N4O7.HCl
- Molecular Weight:593.11
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Omadacycline hydrochloride
More- Nat Microbiol. 2026 Feb 6. [Abstract]
- Nat Microbiol. 2023 Mar;8(3):410-423. [Abstract]
- Nat Struct Mol Biol. 2023 Sep;30(9):1380-1392. [Abstract]
- PLoS Biol. 2022 Sep 28;20(9):e3001808. [Abstract]
- Virulence. 2022 Dec;13(1):77-88. [Abstract]
- J Clin Microbiol. 2020 Jan 28;58(2):e01603-19. [Abstract]
- Antibiotics (Basel). 2022 Sep 23;11(10):1298. [Abstract]
- Ann Lab Med. 2021 May 1;41(3):293-301. [Abstract]
- Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0024925. [Abstract]
- Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0105124. [Abstract]
- Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0063824. [Abstract]
- Antimicrob Agents Chemother. 2023 Feb 16;67(2):e0145922. [Abstract]
- Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02097-19. [Abstract]
- Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00470-19. [Abstract]
- Microbiol Spectr. 2023 Jun 15;11(3):e0071823. [Abstract]
- Microbiol Spectr. 2023 Feb 14;11(1):e0323822. [Abstract]
- J Antimicrob Chemother. 2021 Jul 15;76(8):2071-2078. [Abstract]
- J Antimicrob Chemother. 2021 Feb 11;76(3):653-658. [Abstract]
- Pathology. 2026 Feb 6:S0031-3025(26)00393-4. [Abstract]
- J Microbiol Immunol Infect. 2025 Apr;58(2):219-225. [Abstract]
- Open Forum Infect Dis. 2024 Oct 11;11(11):ofae611. [Abstract]
- J Glob Antimicrob Resist. 2025 Aug 8:44:435-441. [Abstract]
- Malar J. 2025 Jun 19;24(1):194. [Abstract]
- Infect Drug Resist. 2025 Oct 4:18:5239-5247. [Abstract]
- Animal Feed Science and Technology. 2014 Dec;198:323-332.
- J Antibiot (Tokyo). 2026 May 27. [Abstract]
- J Antibiot (Tokyo). 2022 Aug;75(8):463-471. [Abstract]
- Clin Exp Pharmacol Physiol. 2023 Jul;50(7):604-609. [Abstract]
- Diagn Microbiol Infect Dis. 2020 Nov;98(3):115129. [Abstract]
- bioRxiv. 2026 Jan 14.
- Cureus. 2024 Dec 1;16(12):e74917. [Abstract]
- Comput Intell Neurosci. 2022 Apr 25;2022:7636983. [Abstract]
- Research Square Preprint. 2020 Jun.
Customer Validation & Images
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Cell Proliferation/Viability Assay
All Antibiotic Isoforms
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Biological Activity
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Tetracycline |
Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively[2].
Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1196800-39-1
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Appearance Solid
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Molecular Weight 593.11
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Formula C29H40N4O7.HCl
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Color Brown to black
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SMILES
O=C(C1=C(O)[C@@H](N(C)C)[C@@](C[C@@]2([H])C(C(C3=C(O)C(CNCC(C)(C)C)=CC(N(C)C)=C3C2)=O)=C4O)([H])[C@@]4(O)C1=O)N.Cl
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Synonyms
PTK0796 hydrochloride; Amadacycline hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
Publications (33)
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Journal Impact Factor
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Most Recent
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Nat Microbiol
Addendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro. [Abstract]2026 Feb 6. PMID: 41652022 -
Nat Microbiol
Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains. [Abstract]2023 Mar;8(3):410-423. PMID: 36759752 -
Nat Struct Mol Biol
2023 Sep;30(9):1380-1392. PMID: 37550453 -
PLoS Biol
Low levels of tetracyclines select for a mutation that prevents the evolution of high-level resistance to tigecycline. [Abstract]2022 Sep 28;20(9):e3001808. PMID: 36170241 -
Virulence
MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria. [Abstract]2022 Dec;13(1):77-88. PMID: 34951562 -
J Clin Microbiol
Activity of Potential Alternative Treatment Agents for Stenotrophomonas maltophilia Isolates Nonsusceptible to Levofloxacin and/or Trimethoprim-Sulfamethoxazole. [Abstract]2020 Jan 28;58(2):e01603-19. PMID: 31748318 -
Antibiotics (Basel)
Evaluating the Efficacy of Eravacycline and Omadacycline against Extensively Drug-Resistant Acinetobacter baumannii Patient Isolates. [Abstract]2022 Sep 23;11(10):1298. PMID: 36289956 -
Ann Lab Med
In Vitro Activity of the Novel Tetracyclines, Tigecycline, Eravacycline, and Omadacycline, Against Moraxella catarrhalis. [Abstract]2021 May 1;41(3):293-301. PMID: 33303714 -
Antimicrob Agents Chemother
An enoyl-ACP reductase inhibitor, NITD-916, expresses anti- Mycobacterium abscessus activity. [Abstract]2025 Jul 2;69(7):e0024925. PMID: 40407337 -
Antimicrob Agents Chemother
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus. [Abstract]2024 Dec 5;68(12):e0105124. PMID: 39470195 -
Antimicrob Agents Chemother
Omadacycline powder for research procured from unauthorized commercial vendors may be impure and/or unstable. [Abstract]2024 Jul 9;68(7):e0063824. PMID: 38888320 -
Antimicrob Agents Chemother
Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection. [Abstract]2023 Feb 16;67(2):e0145922. PMID: 36688684 -
Antimicrob Agents Chemother
Omadacycline Efficacy against Enterococcus faecalis Isolated in China: In Vitro Activity, Heteroresistance, and Resistance Mechanisms. [Abstract]2020 Feb 21;64(3):e02097-19. PMID: 31871086 -
Antimicrob Agents Chemother
In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of Mycobacterium abscessus. [Abstract]2019 May 24;63(6). pii: e00470-19. PMID: 30962331 -
Microbiol Spectr
Omadacycline, Eravacycline, and Tigecycline Express Anti-Mycobacterium abscessus Activity In Vitro. [Abstract]2023 Jun 15;11(3):e0071823. PMID: 37140428 -
Microbiol Spectr
In Vitro Antimicrobial Activities of Tigecycline, Eravacycline, Omadacycline, and Sarecycline against Rapidly Growing Mycobacteria. [Abstract]2023 Feb 14;11(1):e0323822. PMID: 36475850
Omadacycline hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2023 Feb 14;11(1):e0323822. [Abstract]
The MIC distributions of Omadacycline against 43 M. fortuitum isolates. The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.
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J Antimicrob Chemother
In vitro activity of imipenem/relebactam, meropenem/vaborbactam, ceftazidime/avibactam, cefepime/zidebactam and other novel antibiotics against imipenem-non-susceptible Gram-negative bacilli from Taiwan. [Abstract]2021 Jul 15;76(8):2071-2078. PMID: 33956969 -
J Antimicrob Chemother
Susceptibility of Elizabethkingia spp. to commonly tested and novel antibiotics and concordance between broth microdilution and automated testing methods. [Abstract]2021 Feb 11;76(3):653-658. PMID: 33258923 -
Pathology
In vitro activity of recently introduced Gram-positive-specific antimicrobial agents against Australian methicillin-resistant Staphylococcus aureus isolates. [Abstract]2026 Feb 6:S0031-3025(26)00393-4. PMID: 41760492 -
J Microbiol Immunol Infect
Antimicrobial resistance among imipenem-non-susceptible Escherichia coli and Klebsiella pneumoniae isolates, with an emphasis on novel β-lactam/β-lactamase inhibitor combinations and tetracycline derivatives: The Taiwan surveillance of antimicrobial resistance program, 2020-2022. [Abstract]2025 Apr;58(2):219-225. PMID: 39934015 -
Open Forum Infect Dis
Successful Treatment of Recurrent Extensively Drug-Resistant Elizabethkingia anophelis Bacteremia Secondary to Ventricular Assist Device-Associated Infection. [Abstract]2024 Oct 11;11(11):ofae611. PMID: 39494452 -
J Glob Antimicrob Resist
Susceptibility of multidrug-resistant Escherichia coli and Klebsiella pneumoniae to oral antibiotics in Australia. [Abstract]2025 Aug 8:44:435-441. PMID: 40784378 -
Malar J
2025 Jun 19;24(1):194. PMID: 40537756 -
Infect Drug Resist
In vitro Activity of the Novel Tetracyclines Derivative, Zifanocycline Against Mycobacterium abscessus. [Abstract]2025 Oct 4:18:5239-5247. PMID: 41069760 -
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J Antibiot (Tokyo)
Combined effect of eravacycline and omadacycline with other antimicrobial agents against Acinetobacter Baumannii. [Abstract]2026 May 27. PMID: 42204275 -
J Antibiot (Tokyo)
Comparison of antibacterial activities and resistance mechanisms of omadacycline and tigecycline against Enterococcus faecium. [Abstract]2022 Aug;75(8):463-471. PMID: 35760902 -
Clin Exp Pharmacol Physiol
In vitro susceptibility testing of tetracycline-class antibiotics against slowly growing non-tuberculous mycobacteria. [Abstract]2023 Jul;50(7):604-609. PMID: 37086075 -
Diagn Microbiol Infect Dis
In vitro activity of new tetracycline analogues omadacycline and eravacycline against clinical isolates of Helicobacter pylori collected in China. [Abstract]2020 Nov;98(3):115129. PMID: 32739761 -
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Cureus
2024 Dec 1;16(12):e74917. PMID: 39742159 -
Comput Intell Neurosci
Omadacycline Efficacy against Streptococcus Agalactiae Isolated in China: Correlation between Resistance and Virulence Gene and Biofilm Formation. [Abstract]2022 Apr 25;2022:7636983. PMID: 35510054 -
Solvent & Solubility
H2O : 200 mg/mL (337.21 mM; Need ultrasonic)
DMSO : 50 mg/mL (84.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (84.30 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
Mice: Omadacycline is dissolved in sterile saline. Mice are infected using a 3-mL lock-top sterile syringe with a sterile 25-gauge, 5/8-in. needle. At 1 h postinfection (p.i.), mice are dosed intravenously (i.v.) with omadacycline or comparator compounds of interest at a volume of 10 ml/kg. A minimum of four dose levels are tested per experiment with 5 mice/group. The typical doses tested ranges from 0.11 to 18 mg/kg of body weight, with exceptions for comparators that requires significantly higher or lower doses to achieve 50% efficacy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Durães F, et, al. Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines. Pharmaceuticals (Basel). 2019 Apr 21;12(2):63. [Content Brief]
[2]. Macone AB, et, al. In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother. 2014;58(2):1127-35. [Content Brief]
[3]. Zhanel GG, et, al. Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs. 2020 Feb;80(3):285-313. [Content Brief]
[4]. Markham A, et, al. Omadacycline: First Global Approval. Drugs. 2018 Dec;78(18):1931-1937. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.6860 mL | 8.4301 mL | 16.8603 mL | 42.1507 mL |
| 5 mM | 0.3372 mL | 1.6860 mL | 3.3721 mL | 8.4301 mL | |
| 10 mM | 0.1686 mL | 0.8430 mL | 1.6860 mL | 4.2151 mL | |
| 15 mM | 0.1124 mL | 0.5620 mL | 1.1240 mL | 2.8100 mL | |
| 20 mM | 0.0843 mL | 0.4215 mL | 0.8430 mL | 2.1075 mL | |
| 25 mM | 0.0674 mL | 0.3372 mL | 0.6744 mL | 1.6860 mL | |
| 30 mM | 0.0562 mL | 0.2810 mL | 0.5620 mL | 1.4050 mL | |
| 40 mM | 0.0422 mL | 0.2108 mL | 0.4215 mL | 1.0538 mL | |
| 50 mM | 0.0337 mL | 0.1686 mL | 0.3372 mL | 0.8430 mL | |
| 60 mM | 0.0281 mL | 0.1405 mL | 0.2810 mL | 0.7025 mL | |
| 80 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.5269 mL | |
| H2O | 100 mM | 0.0169 mL | 0.0843 mL | 0.1686 mL | 0.4215 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Omadacycline hydrochloride Related Classifications
HY-14865C Related Classifications
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