1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Omadacycline hydrochloride

Omadacycline hydrochloride (Synonyms: PTK0796 hydrochloride; Amadacycline hydrochloride)

Cat. No.: HY-14865C Purity: 99.87%
Handling Instructions

Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.

For research use only. We do not sell to patients.

Omadacycline hydrochloride Chemical Structure

Omadacycline hydrochloride Chemical Structure

CAS No. : 1196800-39-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 407 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 407 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 312 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Omadacycline hydrochloride:

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Description

Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].

IC50 & Target

bacteria[1]

In Vitro

Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively[2].
Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

593.11

Formula

C₂₉H₄₀N₄O₇.HCl

CAS No.
SMILES

O=C(C1=C(O)[[email protected]@H](N(C)C)[[email protected]@](C[[email protected]@]2([H])C(C(C3=C(O)C(CNCC(C)(C)C)=CC(N(C)C)=C3C2)=O)=C4O)([H])[[email protected]@]4(O)C1=O)N.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 105 mg/mL (177.03 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (84.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6860 mL 8.4301 mL 16.8603 mL
5 mM 0.3372 mL 1.6860 mL 3.3721 mL
10 mM 0.1686 mL 0.8430 mL 1.6860 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (84.30 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.62 mg/mL (4.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Mice: Omadacycline is dissolved in sterile saline. Mice are infected using a 3-mL lock-top sterile syringe with a sterile 25-gauge, 5/8-in. needle. At 1 h postinfection (p.i.), mice are dosed intravenously (i.v.) with omadacycline or comparator compounds of interest at a volume of 10 ml/kg. A minimum of four dose levels are tested per experiment with 5 mice/group. The typical doses tested ranges from 0.11 to 18 mg/kg of body weight, with exceptions for comparators that requires significantly higher or lower doses to achieve 50% efficacy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

OmadacyclinePTK0796AmadacyclinePTK 0796PTK-0796BacterialAntibiotictetracyclineantibacterialagentproteinsynthesisbroadspectrumGram-positiveGram-negativeanaerobicatypicalpathogensacutebacterialskinskin-structureinfectionscommunity-acquiredpneumoniaurinarytractInhibitorinhibitorinhibit

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Product Name:
Omadacycline hydrochloride
Cat. No.:
HY-14865C
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