1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Omadacycline tosylate

Omadacycline tosylate (Synonyms: PTK 0796 tosylate; Amadacycline tosylate)

Cat. No.: HY-14865B Purity: 99.37%
Handling Instructions

Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate exhibits activity against a broad spectrum of bacteria, including Gram-positive, Gram-negative, anaerobic, and atypical pathogens. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.

For research use only. We do not sell to patients.

Omadacycline tosylate Chemical Structure

Omadacycline tosylate Chemical Structure

CAS No. : 1075240-43-5

Size Price Stock Quantity
10 mM * 1 mL in Water USD 500 In-stock
Estimated Time of Arrival: December 31
5 mg USD 312 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 8 publication(s) in Google Scholar

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Description

Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate exhibits activity against a broad spectrum of bacteria, including Gram-positive, Gram-negative, anaerobic, and atypical pathogens. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].

IC50 & Target

bacteria[1]

In Vitro

Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively[2].
Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

728.85

Formula

C₃₆H₄₈N₄O₁₀S

CAS No.

1075240-43-5

SMILES

O=C(C1=C(O)[[email protected]@H](N(C)C)[[email protected]@](C[[email protected]@]2([H])C(C(C3=C(O)C(CNCC(C)(C)C)=CC(N(C)C)=C3C2)=O)=C4O)([H])[[email protected]@]4(O)C1=O)N.OS(=O)(C5=CC=C(C)C=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (17.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3720 mL 6.8601 mL 13.7202 mL
5 mM 0.2744 mL 1.3720 mL 2.7440 mL
10 mM 0.1372 mL 0.6860 mL 1.3720 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

OmadacyclinePTK 0796AmadacyclinePTK0796PTK-0796BacterialAntibiotictetracyclineantibacterialagentproteinsynthesisbroadspectrumGram-positiveGram-negativeanaerobicatypicalpathogensacutebacterialskinskin-structureinfectionscommunity-acquiredpneumoniaurinary tractInhibitorinhibitorinhibit

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Product Name:
Omadacycline tosylate
Cat. No.:
HY-14865B
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