2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3K-IN-1

PI3K-IN-1  (Synonyms: XL-147 derivative 1)

Cat. No.: HY-12068 Purity: 96.02%
COA Handling Instructions

PI3K-IN-1 (XL-147 derivative 1) is a potent inhibitor of PI3K. PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways.

For research use only. We do not sell to patients.

PI3K-IN-1 Chemical Structure

PI3K-IN-1 Chemical Structure

CAS No. : 1349796-36-6

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Solution
10 mM * 1 mL in DMSO USD 117 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 117 In-stock
Solid
2 mg USD 55 In-stock
5 mg USD 88 In-stock
10 mg USD 154 In-stock
25 mg USD 308 In-stock
50 mg USD 440 In-stock
100 mg USD 715 In-stock
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Customer Review

Based on 8 publication(s) in Google Scholar

PI3K-IN-1 Related Antibodies

Top Publications Citing Use of Products

    PI3K-IN-1 purchased from MCE. Usage Cited in: Front Bioeng Biotechnol. 2020 May 8;8:392.  [Abstract]

    Acta2 expression after Signaling inhibitors by q-PCR. For inhibitor treatment, 24 h after seeding, the medium is removed and replaced with the PI3K inhibitor PI3K-IN-1(25 μM) to block the PI3K/Akt signaling pathways.

    View All PI3K Isoform Specific Products:

    View All Isoforms
    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    PI3K-IN-1 (XL-147 derivative 1) is a potent inhibitor of PI3K. PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways[1].

    IC50 & Target[1]

    PI3K

     

    In Vitro

    PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways. By using the PI3K inhibitor PI3K-IN-1, TGF-β1 induced transformation into myofibroblast is also inhibited, with relatively reduced expressions of α-SMA, Col-1 and Timp-1[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    PI3K-IN-1 Related Antibodies
    Molecular Weight

    599.66

    Appearance

    Solid

    Formula

    C31H29N5O6S
    CAS No.
    SMILES

    COC1=CC(NC2=NC3=CC=CC=C3N=C2NS(C4=CC=C(C=C4)NC(C5=CC=C(C(OC)=C5)C)=O)(=O)=O)=CC(OC)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 27.5 mg/mL (45.86 mM; Need ultrasonic and warming)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6676 mL 8.3381 mL 16.6761 mL
    5 mM 0.3335 mL 1.6676 mL 3.3352 mL
    10 mM 0.1668 mL 0.8338 mL 1.6676 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.17 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (4.17 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.93%

    COA (256 KB) LCMS (122 KB)

    Handling Instructions (2659 KB)
    References
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    PI3K-IN-1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    PI3K-IN-11349796-36-6XL-147 derivative 1PI3KPhosphoinositide 3-kinaseSRCgeneextraocularmusclefibrosisophthalmopathythyroidcancerInhibitorinhibitorinhibit

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