1. PI3K/Akt/mTOR
  2. PI3K
  3. PI3K-IN-1

PI3K-IN-1 (Synonyms: XL-147 derivative 1)

Cat. No.: HY-12068 Purity: 99.93%
Handling Instructions

PI3K-IN-1 (XL-147 derivative 1) is a potent inhibitor of PI3K. PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways.

For research use only. We do not sell to patients.

PI3K-IN-1 Chemical Structure

PI3K-IN-1 Chemical Structure

CAS No. : 1349796-36-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
2 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    PI3K-IN-1 purchased from MCE. Usage Cited in: Front Bioeng Biotechnol. 2020 May 8;8:392.

    Acta2 expression after Signaling inhibitors by q-PCR. For inhibitor treatment, 24 h after seeding, the medium is removed and replaced with the PI3K inhibitor PI3K-IN-1(25 μM) to block the PI3K/Akt signaling pathways.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    PI3K-IN-1 (XL-147 derivative 1) is a potent inhibitor of PI3K. PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways[1].

    IC50 & Target[1]

    PI3K

     

    In Vitro

    PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways. By using the PI3K inhibitor PI3K-IN-1, TGF-β1 induced transformation into myofibroblast is also inhibited, with relatively reduced expressions of α-SMA, Col-1 and Timp-1[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    599.66

    Formula

    C₃₁H₂₉N₅O₆S

    CAS No.

    1349796-36-6

    SMILES

    COC1=CC(NC2=NC3=CC=CC=C3N=C2NS(C4=CC=C(C=C4)NC(C5=CC=C(C(OC)=C5)C)=O)(=O)=O)=CC(OC)=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 27.5 mg/mL (45.86 mM; Need ultrasonic and warming)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6676 mL 8.3381 mL 16.6761 mL
    5 mM 0.3335 mL 1.6676 mL 3.3352 mL
    10 mM 0.1668 mL 0.8338 mL 1.6676 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.17 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (4.17 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.93%

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    Keywords:

    PI3K-IN-1XL-147 derivative 1PI3KPhosphoinositide 3-kinaseSRCgeneextraocularmusclefibrosisophthalmopathythyroidcancerInhibitorinhibitorinhibit

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    Product Name:
    PI3K-IN-1
    Cat. No.:
    HY-12068
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