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  3. Parsaclisib

Parsaclisib (Synonyms: INCB050465)

Cat. No.: HY-109068 Purity: 99.31%
Handling Instructions

Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.

For research use only. We do not sell to patients.

Parsaclisib Chemical Structure

Parsaclisib Chemical Structure

CAS No. : 1426698-88-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.

IC50 & Target

IC50: 1 nM (PI3Kδ, 1 mM ATP)[1]

In Vitro

Parsaclisib (INCB050465) is a potent and selective PI3Kδ with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation aaasys. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM)[1].

Clinical Trial
Molecular Weight

432.88

Formula

C₂₀H₂₂ClFN₆O₂

CAS No.

1426698-88-5

SMILES

CCOC1=C([[email protected]@H](C2)CNC2=O)C(F)=C(Cl)C=C1[[email protected]@H](N3C4=NC=NC(N)=C4C(C)=N3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (288.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3101 mL 11.5505 mL 23.1011 mL
5 mM 0.4620 mL 2.3101 mL 4.6202 mL
10 mM 0.2310 mL 1.1551 mL 2.3101 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ParsaclisibINCB050465INCB 050465INCB-050465PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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Parsaclisib
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HY-109068
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