1. PI3K/Akt/mTOR
  2. PI3K

Parsaclisib (Synonyms: INCB050465)

Cat. No.: HY-109068 Purity: 99.20%
Handling Instructions

Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.

For research use only. We do not sell to patients.

Parsaclisib Chemical Structure

Parsaclisib Chemical Structure

CAS No. : 1426698-88-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.

IC50 & Target

IC50: 1 nM (PI3Kδ, 1 mM ATP)[1]

In Vitro

Parsaclisib (INCB050465) is a potent and selective PI3Kδ with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation aaasys. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM)[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3101 mL 11.5505 mL 23.1011 mL
5 mM 0.4620 mL 2.3101 mL 4.6202 mL
10 mM 0.2310 mL 1.1551 mL 2.3101 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

432.88

Formula

C₂₀H₂₂ClFN₆O₂

CAS No.

1426698-88-5

SMILES

CCOC1=C([[email protected]@H](C2)CNC2=O)C(F)=C(Cl)C=C1[[email protected]@H](N3C4=NC=NC(N)=C4C(C)=N3)C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Parsaclisib
Cat. No.:
HY-109068
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Parsaclisib

Cat. No.: HY-109068