Others

CCW16-C2-Boc is a conjugate targeting RNF4, formed by coupling the target protein ligand CCW16 (HY-143346) with a PROTAC Linker. CCW16-C2-Boc can be used to synthesize the PROTAC degrader: PROTAC RNF4 degrader-1 (HY-181693).

(S,R)-Isotentoxin-¹³C₂₂ is the ¹³C-labeled (S,R)-Isotentoxin.

(R,S,R)-Altenuene-¹³C₁₅ is the ¹³C-labeled (R,S,R)-Altenuene. Fumitremorgin C is a potent and selective ABCG2/BRCP inhibitor.

E3 Ligase Ligand-linker Conjugate 225 is an E3 ligase ligand-linker conjugate used for the synthesis of PROTACs; it consists of the PEG-based linker Bis-Tos-PEG3 (HY-W013731) and the VHL-type E3 ubiquitin ligase ligand VH 101 thiol (HY-47851). E3 Ligase Ligand-linker Conjugate 225 can be further coupled with a target protein ligand—such as MT-4 (HY-128595)—to synthesize the PROTAC TG2 Degrader-3 (HY-181732).

TPKI-39 is a DDR1, DDR2, and FLT1 inhibitor, with a human DDR1 IC₅₀ of 380 nM, human DDR1 K_a of 24 nM, human DDR2 IC₅₀ of 120 nM, human FLT1 IC₅₀ of 65 nM, and human FLT1 K_a of 91 nM.TPKI-39 inhibits DDR1 enzymatic activity and autophosphorylation, DDR2 enzymatic activity, and FLT1 enzymatic activity in cells.TPKI-39 inhibits collagen-induced DDR1 autophosphorylation in cells.

VHL Ligand 39 is a conjugate of an E3 ligase ligand, serving as a key intermediate in the synthesis of complete PROTAC molecules.

JQ-1 (carboxylic acid)-NHS is an ester derivative of (+)-JQ-1 (HY-13030). JQ-1 (carboxylic acid)-NHS serves as a negative control.

MV78-OH is a NAMPT ligand that can be used as a target protein ligand to synthesize NAMPT-targeting PROTACs, such as PROTAC NAMPT Degrader-28 (HY-181880).

MV78-OH-C7-COOH is a synthetic target protein ligand-linker conjugate that can be used for the synthesis of PROTACs, such as PROTAC NAMPT Degrader-28 (HY-181880).

AK177 is an allosteric activator of IRE1α ribonuclease, with values of 480 nM and 180 nM against non-phosphorylated and phosphorylated IRE1α, respectively. AK177 promotes IRE1α-mediated cleavage of XBP1 mRNA probe in a concentration-dependent manner and binds stably to its kinase domain. However, AK177 shows poor kinase selectivity, and due to poor membrane permeability at the cellular level, it induces no significant downstream pathway activation or antiproliferative activity.

E3 Ligase Ligand-linker Conjugate 226 is a synthetic E3 ligase ligand-linker conjugate that can be used to synthesize PROTACs, such as PROTAC IRAK3 degrader-2 (HY-181898). GXF-111 is a IRAK PROTAC degrader with anti-tumor activity.

PLM-101-C3-NHBoc is a conjugate of a RET-targeting ligand and a linker, which can be used in the synthesis of PROTAC RET Degrader 2 (HY-181895).

mAb-AsnAsn-E104 is a conjugate of an ADC drug toxin molecule and a linker, which contains a degradable PEG linker and the toxin molecule E104 (HY-156174).

WDR5 ligand 3 is a WDR5 ligand that can be used for the synthesis of PORTACs, such as PROTAC WDR5 degrader 2 (HY-181972).

ATR ligand 2 (Compound 26) is a ATR PROTAC ligand. ATR ligand 2 can be conjugated with E3 ligase Ligand (HY-W077589A) and linker to synthesize PROTAC ATR degrader-3 (HY-182016).

ATR ligand 2-CO-Ph-COOH (Compound 39) is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for ATR (HY-182017) and a PROTAC linker, which recruits E3 ligases. can be used for synthesis of PROTAC ATR degrader-3 (HY-182016).

γ-Glutamyl-S-(2-carboxypropyl)cysteine monoTFA (Standard) is the analytical standard of γ-Glutamyl-S-(2-carboxypropyl)cysteine monoTFA. This product is intended for research and analytical applications. γ-Glutamyl-S-(2-carboxypropyl) cysteine TFA is a chemical intermediate. γ-Glutamyl-S-(2-carboxypropyl) cysteine can be used in the synthesis of Alliin (HY-N0661) and Isoalliin (HY-111825A).

DSPE-PEG1000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG1000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity.

DSPE-PEG5000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG5000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity.

DSPE-PEG2000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG2000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity.