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Cat. No.: HY-181847

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JQ-1 (carboxylic acid)-NHS

JQ-1 (carboxylic acid)-NHS is an ester derivative of (+)-JQ-1 (HY-13030). JQ-1 (carboxylic acid)-NHS serves as a negative control.

For research use only. We do not sell to patients.

CAS No.: 2785405-22-1
Formula: C₂₃H₂₀ClN₅O₄S
Molecular Weight:497.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

JQ-1 (carboxylic acid)-NHS Chemical Structure

CAS No.: 2785405-22-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

JQ-1 (carboxylic acid)-NHS is an ester derivative of (+)-JQ-1 (HY-13030). JQ-1 (carboxylic acid)-NHS serves as a negative control^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	50 μM Compound: 3	Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay	[PMID: 35859867]

In Vitro

JQ-1 (carboxylic acid)-NHS shows no detectable activity in CRBN target binding, BRD4 degradation or cell viability assays in HEK293 cells at concentrations up to 50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2785405-22-1
Molecular Weight 497.95
Formula C₂₃H₂₀ClN₅O₄S
SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(ON4C(CCC4=O)=O)=O)C5=NN=C(C)N25
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hendrick CE, et al. Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation. ACS Med Chem Lett. 2022;13(7):1182-1190. Published 2022 Jun 20. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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