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Cat. No.: HY-181881

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MV78-OH

MV78-OH is a NAMPT ligand that can be used as a target protein ligand to synthesize NAMPT-targeting PROTACs, such as PROTAC NAMPT Degrader-28 (HY-181880).

For research use only. We do not sell to patients.

Formula: C₂₇H₂₉N₅O₂
Molecular Weight:455.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MV78-OH Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

MV78-OH is a NAMPT ligand that can be used as a target protein ligand to synthesize NAMPT-targeting PROTACs, such as PROTAC NAMPT Degrader-28 (HY-181880)^[1].

Chemical Information

Molecular Weight 455.55
Formula C₂₇H₂₉N₅O₂
SMILES

O=C(NCCCCCCCN1N=NC(C2=CC=CN=C2)=C1)C3=CC=CC=C3C4=CC=CC(O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Galli U, et al. Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy. J Med Chem. 2026;69(5):5259-5290. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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