Cathepsin
Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.
Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.
Cathepsin Isoform Specific Products
All Product Categories
-
Cathepsin Inhibitors
(216)
View all products
-
Cathepsin Antagonist
(1)
View all products
-
Cathepsin Activators
(7)
View all products
-
Cathepsin Inducers
(3)
View all products
-
Cathepsin Degrader
(1)
View all products
-
Cathepsin Control
(1)
View all products
-
Cathepsin Substrates
(21)
View all products
-
Cathepsin Ligand
(1)
View all products
-
Cathepsin Proteins
(35)
View all products
-
Cathepsin B Proteins
(5)
View all products
-
Cathepsin C Proteins
(4)
View all products
-
Cathepsin D Proteins
(5)
View all products
-
Cathepsin E Proteins
(3)
View all products
-
Cathepsin K Proteins
(1)
View all products
-
Cathepsin L1 Proteins
(4)
View all products
-
Cathepsin S Proteins
(2)
View all products
-
Cathepsin Related Products (297)
Related Products (297)
-
Recombinant Proteins (35)
-
Antibodies (6)
-
Cathepsin Isoform Comparison
-
SARS-CoV-2-IN-77
0 ImagesCat. No.: HY-163206SARS-CoV-2-IN-77 (compound 11e) is a cathepsin L and cathepsin S inhibitor with Ki values of 111 nM and 103 nM, respectively. SARS-CoV-2-IN-77 inhibits SARS-CoV-2 with an EC50 value of 38.4 nM in Calu-3 cells without showing cytotoxicity.
-
Cathepsin G Inhibitor I (Standard)
0 ImagesCat. No.: HY-103351RCAS No.: 429676-93-7Cathepsin G Inhibitor I (Standard) is the analytical standard of Cathepsin G Inhibitor I (HY-103351). This product is intended for research and analytical applications. Cathepsin G Inhibitor I (compound 7) is an effective, selective, reversible, competitive, non-peptide cathepsin G inhibitor (IC50=53 nM; Ki=63 nM).
-
MPI8
0 ImagesCat. No.: HY-158763CAS No.: 856242-63-2Synonyms: TG0205221MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19.
-
Poly-L-glutamic acid sodium salt (MW 3000)
0 ImagesCat. No.: HY-W596474ACAS No.: 26247-79-0Poly-L-glutamic acid sodium salt (MW 3000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
-
(Rac)-Z-FA-FMK
0 ImagesCat. No.: HY-123185CAS No.: 96922-64-4(Rac)-Z-FA-FMK is the racemate of Z-FA-FMK. (Rac)-Z-FA-FMK is an inhibitor of cathepsin B with a Ki of 1.5 μM. (Rac)-Z-FA-FMK inhibits caspase-2, -3, -6, -7, and -9 with IC50s of 6.147, 15.41, 32.45, 9.077, and 110.7 μM. (Rac)-Z-FA-FMK inhibits the main protease of SARS-CoV-2 replication with an IC50 of 11.39 μM. (Rac)-Z-FA-FMK inhibits the increased IL-1β level induced by LPS and NF-κB transactivation in macrophages.
-
Poly-L-glutamic acid sodium salt (MW 45000)
0 ImagesCat. No.: HY-W596474ECAS No.: 26247-79-0Poly-L-glutamic acid sodium salt (MW 45000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
-
Relacatib (Standard)
0 ImagesCat. No.: HY-10294RCAS No.: 362505-84-8Synonyms: SB-462795 (Standard)Relacatib (Standard) is the analytical standard of Relacatib (HY-10294). This product is intended for research and analytical applications. Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC50 values of 45 nM and 70 nM, respectively. Relacatib inhibits bone resorption in vitro in human tissue as well as in cynomolgus monkeys in vivo.
-
Mpro/Cathepsin L-IN-2
0 ImagesCat. No.: HY-176229Mpro/Cathepsin L-IN-2 (Compound 1) is a dual irreversible inhibitor of SARS-CoV-2 main protease (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64). Mpro/Cathepsin L-IN-2 is promising for research of COVID-19 and other coronavirus infections.
-
L-006235 (Standard)
0 ImagesSynonyms: L-235 (Standard)L-006235 (Standard) is the analytical standard of L-006235. This product is intended for research and analytical applications. L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss.
-
BML-244
0 ImagesCat. No.: HY-113721CAS No.: 104062-70-6BML-244 is a potent cathepsin K inhibitor. BML-244 can be used in the study of rheumatoid arthritis (RA) and periodontitis.
-
Calpeptin (Standard)
0 ImagesCat. No.: HY-100223RCAS No.: 117591-20-5Calpeptin (Standard) is the analytical standard of Calpeptin. This product is intended for research and analytical applications. Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets. Calpeptin is also an inhibitor of cathepsin K.
-
Aloxistatin (Standard)
0 ImagesCat. No.: HY-100229RCAS No.: 88321-09-9Synonyms: E64d (Standard); E64c ethyl ester (Standard)Aloxistatin (Standard) is the analytical standard of Aloxistatin. This product is intended for research and analytical applications. Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV.
-
6-Hydroxytetrangulol
0 ImagesCat. No.: HY-N14403CAS No.: 30954-70-26-Hydroxytetrangulol is a CPP32 protease inducer found in Streptomyces sp.
-
Petesicatib (Standard)
0 ImagesCat. No.: HY-109069RCAS No.: 1252637-35-6Synonyms: RO5459072 (Standard); RG-7625 (Standard)Petesicatib (Standard) is the analytical standard of Petesicatib (HY-109069). This product is intended for research and analytical applications. Petesicatib (RO5459072; RG-7625) is a cathepsin S inhibitor, used in research of immune diseases.
-
SARS-CoV-2 3CLpro-IN-34
0 ImagesCat. No.: HY-179612SARS-CoV-2 3CLpro-IN-34 (Compound 55) is a highly efficient non-covalent inhibitor of the SARS-CoV-2 3CLpro protease (b. SARS-CoV-2 3CLpro protease) with an IC50 of 1.9 μM. SARS-CoV-2 3CLpro-IN-34 can inhibit the 3CLpro protein of SARS-CoV-1, with its IC50 being 3.2 μM, and it shows high selectivity towards host cysteine proteases (such as cathepsins L/K and calpain). SARS-CoV-2 3CLpro-IN-34 exhibits antiviral activity in cells infected with SARS-CoV-2, with its EC50 being 25 μM, and it is not affected by P-gp inhibitors and shows no significant cytotoxicity. SARS-CoV-2 3CLpro-IN-34 can be used for research on SARS-CoV-2 infection.
-
Cathepsin S-IN-1
0 ImagesCat. No.: HY-105668CAS No.: 537706-31-3Cathepsin S-IN-1 (example 1) is a Cathepsin S inhibitor.
-
MDL 27399
0 ImagesCat. No.: HY-123753CAS No.: 131374-22-6MDL 27399 is an inhibitor of human neutrophil cathepsin G (Ki = 7 μM). MDL 27399 can be used for research of inflammatory diseases.
