Cathepsin
Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.
Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.
Cathepsin Isoform Specific Products
All Product Categories
-
Cathepsin Inhibitors
(213)
View all products
-
Cathepsin Antagonist
(1)
View all products
-
Cathepsin Activators
(7)
View all products
-
Cathepsin Inducers
(3)
View all products
-
Cathepsin Degrader
(1)
View all products
-
Cathepsin Control
(1)
View all products
-
Cathepsin Substrates
(21)
View all products
-
Cathepsin Ligand
(1)
View all products
-
Cathepsin Proteins
(35)
View all products
-
Cathepsin B Proteins
(5)
View all products
-
Cathepsin C Proteins
(4)
View all products
-
Cathepsin D Proteins
(5)
View all products
-
Cathepsin E Proteins
(3)
View all products
-
Cathepsin K Proteins
(1)
View all products
-
Cathepsin L1 Proteins
(4)
View all products
-
Cathepsin S Proteins
(2)
View all products
-
Cathepsin Related Products (294)
Related Products (294)
-
Recombinant Proteins (35)
-
Antibodies (6)
-
Cathepsin Isoform Comparison
-
SARS-CoV-2 3CLpro-IN-38
0 ImagesCat. No.: HY-184269SARS-CoV-2 3CLpro-IN-38 is a 3CLpro inhibitor with an IC50 of 0.34 μM against SARS-CoV-2 3CLpro and an IC50 of 0.12 μM against MERS-CoV 3CLpro. SARS-CoV-2 3CLpro-IN-38 inhibits recombinant Cathepsin L with an IC50 of 5.23 nM. SARS-CoV-2 3CLpro-IN-38 inhibits cysteine proteases essential for the replication of SARS-CoV-2 and MERS-CoV, suppresses host cysteine proteases involved in coronavirus entry, blocks viral entry, and inhibits viral replication. SARS-CoV-2 3CLpro-IN-38 can be used in the research of COVID-19.
-
S2160
0 ImagesCat. No.: HY-118959CAS No.: 54799-93-8Synonyms: Bz-Phe-Val-Arg-pNAS2160 is a substrate of Cathepsin B that can be utilized in the calorimetric assay for the measurement of cathepsin B.
-
SQ 32602
0 ImagesCat. No.: HY-124202CAS No.: 169529-81-1SQ 32602 is an inhibitor of cathepsin E, with the IC50 of 88 nM.
-
NCO 700 sulfate
0 ImagesCat. No.: HY-106058ACAS No.: 84579-82-8NCO-700 sulfate is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 sulfate reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 sulfate also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 sulfate can be used to study myocardial ischemia and refractory hormone-independent tumors.
-
Z-LVG-CHN2 (Standard)
0 ImagesCat. No.: HY-108137RCAS No.: 119670-30-3Z-LVG-CHN2 (Standard) is the analytical standard of Z-LVG-CHN2 (HY-108137). This product is intended for research and analytical applications. Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.
-
NC 2300
0 ImagesCat. No.: HY-15099CAS No.: 221144-20-3Synonyms: VEL 0230NC 2300 (VEL-0230)is a selective and orally active cysteine cathepsin inhibitor with the IC50 values of 284, 34.5, and 186 nM for cathepsin B, K, and S, respectively.NC 2300 can be used for study of diseases involving bone mineral disorders.
-
K11002 hydrobromide
0 ImagesCat. No.: HY-183387CAS No.: 1348565-08-1K11002 hydrobromide is a cysteine protease inhibitor. K11002 hydrobromide forms a covalent bond with the active site cysteine residue via Michael addition. K11002 hydrobromide inhibits the growth of Trypanosoma brucei. K11002 hydrobromide can be used in the research of African human trypanosomiasis (sleeping sickness).
-
Odanacatib (Standard)
0 ImagesCat. No.: HY-10042RCAS No.: 603139-19-1Synonyms: MK-0822 (Standard)Odanacatib (Standard) is the analytical standard of Odanacatib (HY-10042). This product is intended for research and analytical applications. Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC50 of 0.2 nM for human cathepsin K.
-
TB-11
0 ImagesTB-11 is a Cathepsin D inhibitor, with IC50s of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), 48.8 nM (BACE1), respectively. TB-11 can be used for tumor research.
-
2-Cyanopyrimidine (Standard)
0 Images2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos.
-
CTSL/B-IN-1
0 ImagesCat. No.: HY-163029CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and TMPRSS2 with IC50s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research.
-
CA-074 (Standard)
0 ImagesCat. No.: HY-103350RCAS No.: 134448-10-5CA-074 (Standard) is the analytical standard of CA-074 (HY-103350). This product is intended for research and analytical applications. CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
-
VK13
0 ImagesCat. No.: HY-170819VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) with a Ki value of 0.55 nM and SARS-CoV-2 3CLpro (3CL-PR) with a Ki value of 2.6 nM. VK13 exhibits anti-CoV-2 activity with an EC50 of 1.25 μM.
-
ONO-5334 (Standard)
0 ImagesCat. No.: HY-108044RCAS No.: 868273-90-9ONO-5334 (Standard) is the analytical standard of ONO-5334 (HY-108044). This product is intended for research and analytical applications. ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease.
-
JPM-OEt (Standard)
0 ImagesCat. No.: HY-102087RCAS No.: 262381-84-0JPM-OEt (Standard) is the analytical standard of JPM-OEt (HY-102087). This product is intended for research and analytical applications. JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity.
-
UAWJ9-36-3
0 ImagesCat. No.: HY-178696CAS No.: 2663864-31-9UAWJ9-36-3 is a Mpro and cathepsin L (IC50: 1.81 μM) inhibitor. UAWJ9-36-3 shows potent binding and enzymatic inhibition against the Mpros from SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HKU1. UAWJ9-36-3 demonstrates broad-spectrum antiviral activity against not only SARS-CoV-2, but also the common human coronaviruses HCoV-OC43, HCoV-NL63, and HCoV-229E.
-
Cathepsin K-IN-9
0 ImagesCat. No.: HY-179697CAS No.: 2361420-28-0Cathepsin K-IN-9 is a selective, potent and orally active Cathepsin K inhibitor with an IC50 of 6.2 nM. Cathepsin K-IN-9 has IC50 > 10000 nM for cathepsin B, L, and S, showing over 1600-fold selectivity. Cathepsin K-IN-9 has excellent safety and metabolic stability.Cathepsin K-IN-9 can be used for the research of osteoporosis.
-
SARS-CoV-2-IN-77
0 ImagesCat. No.: HY-163206SARS-CoV-2-IN-77 (compound 11e) is a cathepsin L and cathepsin S inhibitor with Ki values of 111 nM and 103 nM, respectively. SARS-CoV-2-IN-77 inhibits SARS-CoV-2 with an EC50 value of 38.4 nM in Calu-3 cells without showing cytotoxicity.
-
Cathepsin G Inhibitor I (Standard)
0 ImagesCat. No.: HY-103351RCAS No.: 429676-93-7Cathepsin G Inhibitor I (Standard) is the analytical standard of Cathepsin G Inhibitor I (HY-103351). This product is intended for research and analytical applications. Cathepsin G Inhibitor I (compound 7) is an effective, selective, reversible, competitive, non-peptide cathepsin G inhibitor (IC50=53 nM; Ki=63 nM).
-
MPI8
0 ImagesCat. No.: HY-158763CAS No.: 856242-63-2Synonyms: TG0205221MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19.
