2663864-31-9
Chemical Structure
UAWJ9-36-3
- CAS No.: 2663864-31-9
- Formula:C23H29N3O5
- Molecular Weight:427.49
InChIKey: YVCYGQVRUNWVOI-WTOUUDQASA-N
SMILES: O=C(NCC1)[C@@H]1C[C@@H](C=O)NC(C2[C@]3([H])[C@@](CN2C(OCC4=CC=CC=C4)=O)([H])C3(C)C)=O
Biological Activity: UAWJ9-36-3 is a Mpro and cathepsin L (IC50: 1.81 μM) inhibitor. UAWJ9-36-3 shows potent binding and enzymatic inhibition against the Mpros from SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HKU1. UAWJ9-36-3 demonstrates broad-spectrum antiviral activity against not only SARS-CoV-2, but also the common human coronaviruses HCoV-OC43, HCoV-NL63, and HCoV-229E[1].
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UAWJ9-36-3 | UAWJ9-36-3 is a Mpro and cathepsin L (IC50: 1.81 μM) inhibitor. UAWJ9-36-3 shows potent binding and enzymatic inhibition against the Mpros from SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HKU1. UAWJ9-36-3 demonstrates broad-spectrum antiviral activity against not only SARS-CoV-2, but also the common human coronaviruses HCoV-OC43, HCoV-NL63, and HCoV-229E. | |||||||||||||||||||||
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Keywords