SARS-CoV-2 3CLpro-IN-38
SARS-CoV-2 3CLpro-IN-38 is a 3CLpro inhibitor with an IC50 of 0.34 μM against SARS-CoV-2 3CLpro and an IC50 of 0.12 μM against MERS-CoV 3CLpro. SARS-CoV-2 3CLpro-IN-38 inhibits recombinant Cathepsin L with an IC50 of 5.23 nM. SARS-CoV-2 3CLpro-IN-38 inhibits cysteine proteases essential for the replication of SARS-CoV-2 and MERS-CoV, suppresses host cysteine proteases involved in coronavirus entry, blocks viral entry, and inhibits viral replication. SARS-CoV-2 3CLpro-IN-38 can be used in the research of COVID-19.
For research use only. We do not sell to patients.
- Formula: C27H41N4O8P
- Molecular Weight:580.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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cathepsin L 5.23 nM (IC50) |
SARS-CoV-2 3CLPro 0.34 μM (IC50) |
MERS-CoV 3CLpro 0.12 μM (IC50) |
SARS-CoV-2 3CLpro-IN-38 (Compound 1) (Serial dilutions; 1 h enzyme incubation, 1 h substrate incubation) potently inhibits SARS-CoV-2 3CLpro (Wuhan-Hu-1) with an IC50 of 0.34 μM[1].
SARS-CoV-2 3CLpro-IN-38 (Serial dilutions; 1 h enzyme incubation, 1 h substrate incubation) potently inhibits MERS-CoV 3CLpro (EMC/2012) with an IC50 of 0.12 μM[1].
SARS-CoV-2 3CLpro-IN-38 potently inhibits recombinant human cathepsin L with an IC50 of 5.23 nM[1].
SARS-CoV-2 3CLpro-IN-38 (0.02-2 μM; 30 h) potently inhibits SARS-CoV-2 (Wuhan-Hu-1) replicon in 293T cells with an EC50 of 0.06 μM[1].
SARS-CoV-2 3CLpro-IN-38 (1-100 μM; 72 h) exhibits low cytotoxicity in 293T cells, with a CC50 > 100 μM and a selectivity index of ~1667[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 580.61
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Formula C27H41N4O8P
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SMILES
[H]C([C@@H](NC([C@@H](NC(OC[C@@H]1COP(OC(C)C)(N1CC2=CC=CC=C2)=O)=O)CC(C)C)=O)C[C@@H]3CCNC3=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 3CLpro-IN-38 Related Classifications
HY-184269 Related Classifications
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