SARS-CoV-2 3CLpro-IN-38
SARS-CoV-2 3CLpro-IN-38 is a 3CLpro inhibitor with an IC50 of 0.34 μM against SARS-CoV-2 3CLpro and an IC50 of 0.12 μM against MERS-CoV 3CLpro. SARS-CoV-2 3CLpro-IN-38 inhibits recombinant Cathepsin L with an IC50 of 5.23 nM. SARS-CoV-2 3CLpro-IN-38 inhibits cysteine proteases essential for the replication of SARS-CoV-2 and MERS-CoV, suppresses host cysteine proteases involved in coronavirus entry, blocks viral entry, and inhibits viral replication. SARS-CoV-2 3CLpro-IN-38 can be used in the research of COVID-19.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C27H41N4O8P
- Masse moléculaire:580.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Cathepsin
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Activité biologique
Description
IC50 & Target
[1]|
cathepsin L 5.23 nM (IC50) |
SARS-CoV-2 3CLPro 0.34 μM (IC50) |
MERS-CoV 3CLpro 0.12 μM (IC50) |
In Vitro
SARS-CoV-2 3CLpro-IN-38 (Compound 1) (Serial dilutions; 1 h enzyme incubation, 1 h substrate incubation) potently inhibits SARS-CoV-2 3CLpro (Wuhan-Hu-1) with an IC50 of 0.34 μM[1].
SARS-CoV-2 3CLpro-IN-38 (Serial dilutions; 1 h enzyme incubation, 1 h substrate incubation) potently inhibits MERS-CoV 3CLpro (EMC/2012) with an IC50 of 0.12 μM[1].
SARS-CoV-2 3CLpro-IN-38 potently inhibits recombinant human cathepsin L with an IC50 of 5.23 nM[1].
SARS-CoV-2 3CLpro-IN-38 (0.02-2 μM; 30 h) potently inhibits SARS-CoV-2 (Wuhan-Hu-1) replicon in 293T cells with an EC50 of 0.06 μM[1].
SARS-CoV-2 3CLpro-IN-38 (1-100 μM; 72 h) exhibits low cytotoxicity in 293T cells, with a CC50 > 100 μM and a selectivity index of ~1667[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Masse moléculaire 580.61
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Formule C27H41N4O8P
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SMILES
[H]C([C@@H](NC([C@@H](NC(OC[C@@H]1COP(OC(C)C)(N1CC2=CC=CC=C2)=O)=O)CC(C)C)=O)C[C@@H]3CCNC3=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 3CLpro-IN-38 Related Classifications
HY-184269 Related Classifications
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