221144-20-3
221144-20-3
Chemical Structure
NC 2300
Synonym(s): VEL 0230
- CAS No.: 221144-20-3
- Formula:C14H24NNaO5
- Molecular Weight:309.33
IUPAC Name: sodium (2S,3S)-3-(((S)-1-isobutoxy-4-methylpentan-2-yl)carbamoyl)oxirane-2-carboxylate
InChIKey: SGAKODIXAHVUKL-LFELFHSZSA-M
SMILES: CC(C)COC[C@H](CC(C)C)NC([C@@H]1[C@H](O1)C(O[Na])=O)=O
Biological Activity: NC 2300 (VEL-0230)is a selective and orally active cysteine cathepsin inhibitor with the IC50 values of 284, 34.5, and 186 nM for cathepsin B, K, and S, respectively.NC 2300 can be used for study of diseases involving bone mineral disorders[1][2].
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NC 2300 | NC 2300 (VEL-0230)is a selective and orally active cysteine cathepsin inhibitor with the IC50 values of 284, 34.5, and 186 nM for cathepsin B, K, and S, respectively.NC 2300 can be used for study of diseases involving bone mineral disorders. | |||||||||||||||||||||
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References
- [1]. Aoki T,et al. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke. 2008;39(9):2603-2610. [Content Brief]
- [2]. Hirai T, et al. Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation [published correction appears in J Immunol. 2014 May 15;192(10):4933]. J Immunol. 2013;190(9):4805-4811. [Content Brief]
Keywords
