868273-90-9
Chemical Structure
ONO-5334
- CAS No.: 868273-90-9
- Formula:C21H34N4O4S
- Molecular Weight:438.58
IUPAC Name: N-((S)-3-(2-((R,Z)-3,4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl)cycloheptanecarboxamide
InChIKey: BTZCSXIUAFVRTE-CHGLIHOBSA-N
SMILES: O=C(C(N/N=C(SC[C@H]1C)/N1C)=O)[C@H](C2CCOCC2)NC(C3CCCCCC3)=O
Biological Activity: ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ONO-5334 | 99.94% | ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ONO-5334 (Standard) | ONO-5334 (Standard) is the analytical standard of ONO-5334 (HY-108044). This product is intended for research and analytical applications. ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.48
HY-116023Moveltipril -
Similarity Score 0.46
HY-Z8380Ramipril impurity 7 -
Similarity Score 0.44
HY-W587742Dicyclohexylammonium 3-hydroxy-1-methylpropylmercapturic acid -
Similarity Score 0.44
HY-W046352(Cyclohexanecarbonyl)-L-leucine -
Similarity Score 0.44
HY-19660Inogatran -
Similarity Score 0.43
HY-153121Leritrelvir -
Similarity Score 0.42
HY-136800Posatirelin -
Similarity Score 0.42
HY-117961Candoxatrilat -
Similarity Score 0.42
HY-B1433Perindoprilat -
Explore the MedChemAI to find more analogs
