2. Signaling Pathways
  3. Epigenetics
  4. DNA Methyltransferase
  5. DNMT3 Isoform
  6. DNMT3 Degrader

DNMT3 Degrader

DNMT3 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-181955
    MS1129
    		Degrader
    MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins. MS1129 upregulates TRAIL, DR4 and DR5 proteins, downregulates the decoy receptor DcR2, and activates TRAIL-dependent apoptosis via the HIF-1/2 and Caspase-10 pathways. MS1129 is applicable to the research of VHL-deficient clear cell renal cell carcinoma.