2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Potassium Channel
  5. Voltage-gated potassium channel Isoform
  6. Voltage-gated potassium channel Modulator

Voltage-gated potassium channel Modulator

Voltage-gated potassium channel Modulators (3):

Cat. No. Product Name Effect Purity
  • HY-180464
    Kv7.2/Kv7.3 modulator-3
    		Modulator
    Kv7.2/Kv7.3 modulator-3 (example 40 peak-1) is a selective Kv7.2/Kv7.3 modulator with an EC50 of 0.099 μM.
  • HY-108587
    ICA 110381
    		Modulator 99.80%
    ICA 110381 is an orally active Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator with anticonvulsive properties. ICA 110381 is a KCNQ2/Q3 activator (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM).
  • HY-186062
    HCN-IN-1
    		Modulator
    HCN-IN-1 is a TLR4 inhibitor and HCN channel modulator with activity against HCN2 and HCN4.HCN-IN-1 inhibits TLR4-mediated alkaline phosphatase (SEAP) signal activity.HCN-IN-1 reduces HCN2 current across tested voltages, shifts voltage-dependent activation to more hyperpolarized potentials, slows activation kinetics, and does not affect deactivation process.HCN-IN-1 blocks HCN4 current.HCN-IN-1 exhibits analgesic, anti-inflammatory, and anti-anginal effects.HCN-IN-1 can be used for the research of inflammatory pain, neuropathic pain, heart failure, inflammation.