RIP kinase
Receptor-interacting protein kinases; RIPK
Receptor-interacting protein (RIP) kinases are a group of threonine/serine protein kinases with a relatively conserved kinase domain but distinct non-kinase regions. There are seven members of the RIPK family, RIPK1-7, some of which have emerged as critical effectors of immunity to infection with a diverse array of bacterial, viral, and protozoal pathogens.
RIP kinases are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key mediators of intracellular signal transduction including inflammation, autophagy and programmed cell death, and are thus essential for the early control of many diverse pathogenic organisms.
RIP kinase Isoform Specific Products
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RIP kinase Inhibitors
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RIP kinase Activators
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RIP kinase Modulator
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RIP kinase Degraders
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RIP kinase Controls
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RIP kinase Ligands
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Receptor-interacting Serine/Threonine-protein Kinase 3 (RIPK3) Proteins
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RIP kinase Related Products (210)
Related Products (210)
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Recombinant Proteins (3)
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Antibodies (2)
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RIP kinase Isoform Comparison
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Nec-4
0 ImagesCat. No.: HY-18900CAS No.: 1041644-43-2Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
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Nec-34i
0 ImagesCat. No.: HY-W674387CAS No.: 2212541-00-7Nec-34i is an inactive analog structurally similar to Nec-34 (HY-132203). Nec-34i has no effect on RIPK1 kinase activity and cannot inhibit necroptosis.
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RIPK1-IN-12
0 ImagesCat. No.: HY-144277CAS No.: 2173556-92-6RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 values of 1.6 and 2.9 nM, respectively.
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RIPK1-IN-28
0 ImagesCat. No.: HY-170544CAS No.: 2968509-28-4RIPK1-IN-28 (compound 13) is an orally active RIPK1 inhibitor. RIPK1-IN-28 inhibits human I2.1 and Hepa1‐6 cells with IC50s of 0.4 and 1.2 nM, respectively.
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VDX-111
0 ImagesCat. No.: HY-156920CAS No.: 158983-23-4VDX-111 is an analog of vitamin D. VDX-111 exhibits cytotoxicity in ovarian cancer cells through upregulation of RIPK1/RIPK3 pathway and induction of necroptosis. VDX-111 promotes expressions of cytokines and exhibits antitumor activity in mouse model.
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UH15-38 TFA
0 ImagesCat. No.: HY-158312APurity: 99.77%UH15-38 TFA is a potent RIPK3 inhibitor with an IC50 value of 20 nM. UH15-38 TFA blocks IAV (influenza A virus)-activated necroptosis. UH15-38 TFA dampens IAV-induced lung injury.
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RIP1 kinase inhibitor 8
0 ImagesCat. No.: HY-155804CAS No.: 2226735-54-0RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species.
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RIPK1-IN-14
0 ImagesCat. No.: HY-146758CAS No.: 2919964-79-5RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 with an IC50 value of 92 nM. RIPK1-IN-14 shows a significant anti-necroptotic effect in a necroptosis model in U937 cells.
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RIPK2/3-IN-1
0 ImagesCat. No.: HY-155151CAS No.: 3052742-91-0
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SZM-1209
0 ImagesCat. No.: HY-149052CAS No.: 2919801-86-6SZM-1209 is an orally active, potent and specific RIPK1 inhibitor, with a Kd of 85 nM. SZM-1209 exhibits high anti-necroptotic activity (EC50=22.4 ± 8.1 nM). SZM-1209 shows anti-SIRS (systemic inflammatory response syndrome), and anti-ALI (acute lung injury) effects.
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TNF-α-IN-19
0 ImagesCat. No.: HY-114573CAS No.: 338773-13-0TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β.
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RIPK3-IN-4
0 ImagesCat. No.: HY-156368CAS No.: 2304617-58-9RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. RIPK3-IN-4 inhibits HK-2 cell damage, necroptosis and inflammatory responses. RIPK3-IN-4 reduces Cisplatin (HY-17394)- and I/R-induced kidney damage, inflammatory response and necroptosis in acute kidney injury.
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RIPK1-IN-22
0 ImagesCat. No.: HY-162237RIPK1-IN-13 (compound 28) is a selective inhibitor for receptor-interacting serine/threonine-protein kinase 1 (RIPK1), the inhibitory activity is measured by ADP-Glo Kinase Assay with a pKi of 7.66. RIPK1-IN-13 inhibits human leukaemia cells U937 with a pIC50 of 7.2.
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RIPK1-ligand-4
0 ImagesCat. No.: HY-187391CAS No.: 3033385-55-3RIPK1-ligand-4 is a RIMTAC E3 recruiting ligand that indirectly recruits VHL E3 ligases by binding to RIPK1 and hijacking the endogenous RIPK1-VHL complex. RIPK1-ligand-4 can be used to synthesize the BRD4 RIMTAC-1 (HY-187390) PROTAC degrader.
